Names & Taxonomy
- Uniprot ID:
- P15056
- Entry Name:
- BRAF_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)
- Gene Names:
- BRAF BRAF1 RAFB1
- Gene Names Primary:
- BRAF
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 766
- Sequence:
- MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Activity is increased by EGF and HGF.
- Active Site:
- ACT_SITE 576 576 Proton acceptor.
- Cross Reference Drug Bank:
- DB08912 DB08896 DB00398 DB08881
- Gene Ontology Go:
- cell body
cytoplasm
cytosol
intracellular membrane-bounded organelle
mitochondrion
neuron projection
nucleus
plasma membrane
ATP binding
calcium ion binding
identical protein binding
MAP kinase kinase kinase activity
protein kinase activity
protein serine/threonine kinase activity
activation of MAPKK activity
axon guidance
CD4-positive, alpha-beta T cell differentiation
cellular response to calcium ion
cellular response to drug
epidermal growth factor receptor signaling pathway
establishment of protein localization to membrane
face development
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glucose transport
head morphogenesis
innate immune response
insulin receptor signaling pathway
long-term synaptic potentiation
MAPK cascade
myeloid progenitor cell differentiation
negative regulation of apoptotic process
negative regulation of endothelial cell apoptotic process
negative regulation of fibroblast migration
negative regulation of neuron apoptotic process
negative regulation of synaptic vesicle exocytosis
neurotrophin TRK receptor signaling pathway
organ morphogenesis
positive regulation of axon regeneration
positive regulation of axonogenesis
positive regulation of ERK1 and ERK2 cascade
positive regulation of gene expression
positive regulation of peptidyl-serine phosphorylation
positive regulation of stress fiber assembly
positive regulation of substrate adhesion-dependent cell spreading
positive T cell selection
protein heterooligomerization
protein phosphorylation
Ras protein signal transduction
regulation of cell proliferation
response to cAMP
small GTPase mediated signal transduction
somatic stem cell population maintenance
synaptic transmission
thymus development
thyroid gland development
vascular endothelial growth factor receptor signaling pathway
visual learning - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
CD4-positive, alpha-beta T cell differentiation
cellular response to calcium ion
cellular response to drug
epidermal growth factor receptor signaling pathway
establishment of protein localization to membrane
face development
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glucose transport
head morphogenesis
innate immune response
insulin receptor signaling pathway
long-term synaptic potentiation
MAPK cascade
myeloid progenitor cell differentiation
negative regulation of apoptotic process
negative regulation of endothelial cell apoptotic process
negative regulation of fibroblast migration
negative regulation of neuron apoptotic process
negative regulation of synaptic vesicle exocytosis
neurotrophin TRK receptor signaling pathway
organ morphogenesis
positive regulation of axonogenesis
positive regulation of axon regeneration
positive regulation of ERK1 and ERK2 cascade
positive regulation of gene expression
positive regulation of peptidyl-serine phosphorylation
positive regulation of stress fiber assembly
positive regulation of substrate adhesion-dependent cell spreading
positive T cell selection
protein heterooligomerization
protein phosphorylation
Ras protein signal transduction
regulation of cell proliferation
response to cAMP
small GTPase mediated signal transduction
somatic stem cell population maintenance
synaptic transmission
thymus development
thyroid gland development
vascular endothelial growth factor receptor signaling pathway
visual learning - Gene Ontology Molecular Function:
- ATP binding
calcium ion binding
identical protein binding
MAP kinase kinase kinase activity
protein kinase activity
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cell body
cytoplasm
cytosol
intracellular membrane-bounded organelle
mitochondrion
neuron projection
nucleus
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Cardiomyopathy
Cell membrane
Chromosomal rearrangement
Complete proteome
Cytoplasm
Deafness
Direct protein sequencing
Disease mutation
Ectodermal dysplasia
Isopeptide bond
Kinase
Membrane
Mental retardation
Metal-binding
Methylation
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
Serine/threonine-protein kinase
Transferase
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- Itself; P10398; P08238; Q61097; Q02750; P36507; Q13233; P04049; Q99N57; Q8CGE9; Q15349; Q13114; P31946; P63104
Publication
- PubMed ID:
- 1508179 12690205 12853948 15489334 1630826 2284096 18974108 3043188 11410590 16964243 18691976 18669648 19710016 19690332 20068231 21441910 21917714 21406692 22628551 23907581 24275569 18287029 12460919 12068308 12198537 14612909 14500344 16474404 16959974 16439621 17344846 18042262 19206169 23263490 24455489