Names & Taxonomy
- Uniprot ID:
- P14867
- Entry Name:
- GBRA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1)
- Gene Names:
- GABRA1
- Gene Names Primary:
- GABRA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 456
- Sequence:
- MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
- Cross Reference Drug Bank:
- DB00659 DB00546 DB00404 DB01351 DB00543 DB01352 DB01558 DB00237 DB00241 DB01353 DB00475 DB01594 DB00349 DB01068 DB00628 DB01559 DB01189 DB00829 DB00228 DB01049 DB01215 DB00402 DB00898 DB00189 DB00292 DB01567 DB01205 DB00690 DB01381 DB01437 DB00801 DB01159 DB01354 DB01355 DB00753 DB01587 DB00186 DB00371 DB00474 DB01028 DB00849 DB01107 DB00683 DB01595 DB00334 DB00842 DB00312 DB01174 DB01588 DB00794 DB00837 DB00818 DB01589 DB01346 DB00418 DB01236 DB00306 DB00231 DB01154 DB00599 DB00273 DB00897 DB00962 DB00425 DB01198
- Gene Ontology Go:
- cell junction
chloride channel complex
GABA receptor complex
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
chloride channel activity
drug binding
extracellular ligand-gated ion channel activity
GABA-A receptor activity
cellular response to histamine
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
synaptic transmission
synaptic transmission, GABAergic
transmembrane transport
transport - Gene Ontology Biological Process:
- cellular response to histamine
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
synaptic transmission
synaptic transmission, GABAergic
transmembrane transport
transport - Gene Ontology Molecular Function:
- chloride channel activity
drug binding
extracellular ligand-gated ion channel activity
GABA-A receptor activity - Gene Ontology Cellular Component:
- cell junction
chloride channel complex
GABA-A receptor complex
GABA receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane - Keywords:
- Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport