Names & Taxonomy
- Uniprot ID:
- P14778
- Entry Name:
- IL1R1_HUMAN
- Status:
- reviewed
- Protein Names:
- Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
- Gene Names:
- IL1R1 IL1R IL1RA IL1RT1
- Gene Names Primary:
- IL1R1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 569
- Sequence:
- MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
- Cross Reference Drug Bank:
- DB00026
- Gene Ontology Go:
- axon
cell surface
extracellular space
integral component of plasma membrane
membrane
nucleus
plasma membrane
postsynaptic density
protein complex
interleukin-1 receptor activity
interleukin-1, Type I, activating receptor activity
platelet-derived growth factor receptor binding
signal transducer activity
transmembrane signaling receptor activity
cell surface receptor signaling pathway
cellular response to glucose stimulus
heat acclimation
immune response
interleukin-1-mediated signaling pathway
ovulation
regulation of inflammatory response
response to epidermal growth factor
response to interleukin-1
response to nitric oxide
response to radiation
response to transforming growth factor beta - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
cellular response to glucose stimulus
heat acclimation
immune response
interleukin-1-mediated signaling pathway
ovulation
regulation of inflammatory response
response to epidermal growth factor
response to interleukin-1
response to nitric oxide
response to radiation
response to transforming growth factor beta - Gene Ontology Molecular Function:
- interleukin-1, Type I, activating receptor activity
interleukin-1 receptor activity
platelet-derived growth factor receptor binding
signal transducer activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- axon
cell surface
extracellular space
integral component of plasma membrane
membrane
nucleus
plasma membrane
postsynaptic density
protein complex - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q9Y4K3