Names & Taxonomy
- Uniprot ID:
- P14735
- Entry Name:
- IDE_HUMAN
- Status:
- reviewed
- Protein Names:
- Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
- Gene Names:
- IDE
- Gene Names Primary:
- IDE
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1019
- Sequence:
- MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Cell membrane. Secreted
Function
- Function:
- Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
- Catalytic Activity:
- Degradation of insulin, glucagon and other polypeptides. No action on proteins.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by small peptides (By similarity). Activated by ATP and GTP, and to a lesser extent by CTP, TTP and PPPi. Inhibited by bacitracin. Inhibited by S-nitrosylation and oxidation agents.
- Active Site:
- ACT_SITE 111 111 Proton acceptor.
- Cross Reference Drug Bank:
- DB00626 DB00030
- Gene Ontology Go:
- cell surface
cytoplasm
cytosol
cytosolic proteasome complex
extracellular space
mitochondrion
nucleoplasm
nucleus
peroxisomal matrix
peroxisome
plasma membrane
ATP binding
ATPase activity
beta-amyloid binding
beta-endorphin binding
glycoprotein binding
insulin binding
metalloendopeptidase activity
peptide binding
protein homodimerization activity
receptor binding
ubiquitin binding
virus receptor activity
zinc ion binding
beta-amyloid metabolic process
bradykinin catabolic process
determination of adult lifespan
hormone catabolic process
insulin catabolic process
insulin metabolic process
insulin receptor signaling pathway
negative regulation of proteolysis
positive regulation of protein oligomerization
protein heterooligomerization
protein homooligomerization
protein homotetramerization
protein processing
proteolysis
proteolysis involved in cellular protein catabolic process
ubiquitin homeostasis - Gene Ontology Biological Process:
- beta-amyloid metabolic process
bradykinin catabolic process
determination of adult lifespan
hormone catabolic process
insulin catabolic process
insulin metabolic process
insulin receptor signaling pathway
negative regulation of proteolysis
positive regulation of protein oligomerization
protein heterooligomerization
protein homooligomerization
protein homotetramerization
protein processing
proteolysis
proteolysis involved in cellular protein catabolic process
ubiquitin homeostasis - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
beta-amyloid binding
beta-endorphin binding
glycoprotein binding
insulin binding
metalloendopeptidase activity
peptide binding
protein homodimerization activity
receptor binding
ubiquitin binding
virus receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- cell surface
cytoplasm
cytosol
cytosolic proteasome complex
extracellular space
mitochondrion
nucleoplasm
nucleus
peroxisomal matrix
peroxisome
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Allosteric enzyme
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
Host cell receptor for virus entry
Host-virus interaction
Hydrolase
Membrane
Metal-binding
Metalloprotease
Nucleotide-binding
Polymorphism
Protease
Receptor
Reference proteome
Secreted
Zinc - Interacts With:
- P10147