Names & Taxonomy

Uniprot ID:
P14672
Entry Name:
GTR4_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
Gene Names:
SLC2A4 GLUT4
Gene Names Primary:
SLC2A4
Organism:
Homo sapiens (Human)

Structure

Length:
509
Sequence:
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Insulin-regulated facilitative glucose transporter.
Gene Ontology Go:
clathrin-coated vesicle
coated pit
cytoplasmic vesicle membrane
cytosol
endomembrane system
external side of plasma membrane
extracellular exosome
insulin-responsive compartment
integral component of plasma membrane
membrane
membrane raft
multivesicular body
perinuclear region of cytoplasm
plasma membrane
T-tubule
trans-Golgi network transport vesicle
vesicle membrane
D-glucose transmembrane transporter activity
glucose transmembrane transporter activity
amylopectin biosynthetic process
brown fat cell differentiation
carbohydrate metabolic process
cellular response to hypoxia
cellular response to insulin stimulus
cellular response to osmotic stress
glucose homeostasis
glucose import
glucose transport
hexose transport
membrane organization
response to ethanol
small molecule metabolic process
transmembrane transport
Gene Ontology Biological Process:
amylopectin biosynthetic process
brown fat cell differentiation
carbohydrate metabolic process
cellular response to hypoxia
cellular response to insulin stimulus
cellular response to osmotic stress
glucose homeostasis
glucose import
glucose transport
hexose transport
membrane organization
response to ethanol
small molecule metabolic process
transmembrane transport
Gene Ontology Molecular Function:
D-glucose transmembrane transporter activity
glucose transmembrane transporter activity
Gene Ontology Cellular Component:
clathrin-coated vesicle
coated pit
cytoplasmic vesicle membrane
cytosol
endomembrane system
external side of plasma membrane
extracellular exosome
insulin-responsive compartment
integral component of plasma membrane
membrane
membrane raft
multivesicular body
perinuclear region of cytoplasm
plasma membrane
trans-Golgi network transport vesicle
T-tubule
vesicle membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Diabetes mellitus
Disease mutation
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix
Transport
Ubl conjugation

Publication

PubMed ID:
2656669 1397719 16625196 15489334 7916714 8300557 11842083 16647043 17382906 18669648 19349973 1918382 1756912 1521731