Names & Taxonomy
- Uniprot ID:
- P14543
- Entry Name:
- NID1_HUMAN
- Status:
- reviewed
- Protein Names:
- Nidogen-1 (NID-1) (Entactin)
- Gene Names:
- NID1 NID
- Gene Names Primary:
- NID1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1247
- Sequence:
- MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix, basement membrane.
Function
- Function:
- Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
- Cross Reference Drug Bank:
- DB00013
- Gene Ontology Go:
- basal lamina
basement membrane
cell periphery
extracellular exosome
extracellular matrix
extracellular region
calcium ion binding
collagen binding
laminin binding
proteoglycan binding
basement membrane organization
cell-matrix adhesion
extracellular matrix disassembly
extracellular matrix organization
glomerular basement membrane development
positive regulation of cell-substrate adhesion - Gene Ontology Biological Process:
- basement membrane organization
cell-matrix adhesion
extracellular matrix disassembly
extracellular matrix organization
glomerular basement membrane development
positive regulation of cell-substrate adhesion - Gene Ontology Molecular Function:
- calcium ion binding
collagen binding
laminin binding
proteoglycan binding - Gene Ontology Cellular Component:
- basal lamina
basement membrane
cell periphery
extracellular exosome
extracellular matrix
extracellular region - Keywords:
- 3D-structure
Alternative splicing
Basement membrane
Calcium
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Sulfation