Names & Taxonomy
- Uniprot ID:
- P14324
- Entry Name:
- FPPS_HUMAN
- Status:
- reviewed
- Protein Names:
- Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)
- Gene Names:
- FDPS FPS KIAA1293
- Gene Names Primary:
- FDPS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 419
- Sequence:
- MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
- Pathway:
- Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.; Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
- Catalytic Activity:
- Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 3 Mg(2+) ions per subunit.;
- Enzyme Regulation:
- ENZYME REGULATION: Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.
- Cross Reference Drug Bank:
- DB00630 DB00710 DB00282 DB00884 DB00399
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
dimethylallyltranstransferase activity
geranyltranstransferase activity
metal ion binding
poly(A) RNA binding
cholesterol biosynthetic process
farnesyl diphosphate biosynthetic process
geranyl diphosphate biosynthetic process
small molecule metabolic process
viral process - Gene Ontology Biological Process:
- cholesterol biosynthetic process
farnesyl diphosphate biosynthetic process
geranyl diphosphate biosynthetic process
small molecule metabolic process
viral process - Gene Ontology Molecular Function:
- dimethylallyltranstransferase activity
geranyltranstransferase activity
metal ion binding
poly(A) RNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Cytoplasm
Disease mutation
Host-virus interaction
Isoprene biosynthesis
Lipid biosynthesis
Lipid metabolism
Magnesium
Metal-binding
Polymorphism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transferase