Names & Taxonomy
- Uniprot ID:
- P14210
- Entry Name:
- HGF_HUMAN
- Status:
- reviewed
- Protein Names:
- Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]
- Gene Names:
- HGF HPTA
- Gene Names Primary:
- HGF
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 728
- Sequence:
- MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS
- Proteomes:
- UP000005640
Function
- Function:
- Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
- Gene Ontology Go:
- extracellular region
extracellular space
membrane
platelet alpha granule lumen
chemoattractant activity
growth factor activity
identical protein binding
serine-type endopeptidase activity
activation of MAPK activity
blood coagulation
cell chemotaxis
cellular response to hepatocyte growth factor stimulus
epithelial to mesenchymal transition
hepatocyte growth factor receptor signaling pathway
hyaluronan metabolic process
liver development
mitotic nuclear division
morphogenesis of a branching epithelium
myoblast proliferation
negative regulation of autophagy
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of inflammatory response
negative regulation of interleukin-6 production
negative regulation of peptidyl-serine phosphorylation
negative regulation of release of cytochrome c from mitochondria
organ regeneration
platelet activation
platelet degranulation
positive chemotaxis
positive regulation of angiogenesis
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of DNA biosynthetic process
positive regulation of interleukin-10 production
positive regulation of myelination
positive regulation of neuron projection regeneration
positive regulation of osteoblast differentiation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of transcription from RNA polymerase II promoter
proteolysis
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
regulation of p38MAPK cascade
regulation of tau-protein kinase activity - Gene Ontology Biological Process:
- activation of MAPK activity
blood coagulation
cell chemotaxis
cellular response to hepatocyte growth factor stimulus
epithelial to mesenchymal transition
hepatocyte growth factor receptor signaling pathway
hyaluronan metabolic process
liver development
mitotic nuclear division
morphogenesis of a branching epithelium
myoblast proliferation
negative regulation of autophagy
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of inflammatory response
negative regulation of interleukin-6 production
negative regulation of peptidyl-serine phosphorylation
negative regulation of release of cytochrome c from mitochondria
organ regeneration
platelet activation
platelet degranulation
positive chemotaxis
positive regulation of angiogenesis
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of DNA biosynthetic process
positive regulation of interleukin-10 production
positive regulation of myelination
positive regulation of neuron projection regeneration
positive regulation of osteoblast differentiation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of transcription from RNA polymerase II promoter
proteolysis
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
regulation of p38MAPK cascade
regulation of tau-protein kinase activity - Gene Ontology Molecular Function:
- chemoattractant activity
growth factor activity
identical protein binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- extracellular region
extracellular space
membrane
platelet alpha granule lumen - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Deafness
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Kringle
Non-syndromic deafness
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Repeat
Serine protease homolog
Signal - Interacts With:
- Q6UY14-3; A4D127; P08581; P16056