Names & Taxonomy

Uniprot ID:
P13929
Entry Name:
ENOB_HUMAN
Status:
reviewed
Protein Names:
Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase)
Gene Names:
ENO3
Gene Names Primary:
ENO3
Organism:
Homo sapiens (Human)

Structure

Length:
434
Sequence:
MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKGRYLGKGVLKAVENINNTLGPALLQKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLDFKSPDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAIFAGRKFRNPKAK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity).

Function

Function:
Appears to have a function in striated muscle development and regeneration.
Pathway:
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
Catalytic Activity:
2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Mg(2+) is required for catalysis and for stabilizing the dimer.;
Active Site:
ACT_SITE 210 210 Proton donor.
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
extracellular space
phosphopyruvate hydratase complex
plasma membrane
magnesium ion binding
phosphopyruvate hydratase activity
aging
canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
response to drug
skeletal muscle tissue regeneration
small molecule metabolic process
Gene Ontology Biological Process:
aging
canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
response to drug
skeletal muscle tissue regeneration
small molecule metabolic process
Gene Ontology Molecular Function:
magnesium ion binding
phosphopyruvate hydratase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
extracellular space
phosphopyruvate hydratase complex
plasma membrane
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Glycogen storage disease
Glycolysis
Lyase
Magnesium
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome

Publication

PubMed ID:
2587223 2336366 1840492 8513787 14702039 16625196 15489334 15188056 21269460 22814378 24275569 11506403