Names & Taxonomy
- Uniprot ID:
- P13929
- Entry Name:
- ENOB_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase)
- Gene Names:
- ENO3
- Gene Names Primary:
- ENO3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 434
- Sequence:
- MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKGRYLGKGVLKAVENINNTLGPALLQKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLDFKSPDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAIFAGRKFRNPKAK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity).
Function
- Function:
- Appears to have a function in striated muscle development and regeneration.
- Pathway:
- Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
- Catalytic Activity:
- 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Mg(2+) is required for catalysis and for stabilizing the dimer.;
- Active Site:
- ACT_SITE 210 210 Proton donor.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
extracellular space
phosphopyruvate hydratase complex
plasma membrane
magnesium ion binding
phosphopyruvate hydratase activity
aging
canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
response to drug
skeletal muscle tissue regeneration
small molecule metabolic process - Gene Ontology Biological Process:
- aging
canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
response to drug
skeletal muscle tissue regeneration
small molecule metabolic process - Gene Ontology Molecular Function:
- magnesium ion binding
phosphopyruvate hydratase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
extracellular space
phosphopyruvate hydratase complex
plasma membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Glycogen storage disease
Glycolysis
Lyase
Magnesium
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome