Names & Taxonomy
- Uniprot ID:
- P13569
- Entry Name:
- CFTR_HUMAN
- Status:
- reviewed
- Protein Names:
- Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 3.6.3.49) (cAMP-dependent chloride channel)
- Gene Names:
- CFTR ABCC7
- Gene Names Primary:
- CFTR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1480
- Sequence:
- MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Early endosome membrane
Function
- Function:
- Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
- Catalytic Activity:
- ATP + H(2)O = ADP + phosphate.
- Cross Reference Drug Bank:
- DB00887 DB04941 DB01016 DB01050 DB08820
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
cell surface
chloride channel complex
cytoplasm
cytosol
early endosome
early endosome membrane
extracellular exosome
Golgi-associated vesicle membrane
lysosomal membrane
plasma membrane
protein complex
recycling endosome
ATP binding
ATP-binding and phosphorylation-dependent chloride channel activity
bicarbonate transmembrane transporter activity
channel-conductance-controlling ATPase activity
chloride channel activity
chloride channel inhibitor activity
chloride transmembrane transporter activity
enzyme binding
PDZ domain binding
cellular response to cAMP
chloride transmembrane transport
cholesterol biosynthetic process
cholesterol transport
intracellular pH elevation
membrane hyperpolarization
positive regulation of cyclic nucleotide-gated ion channel activity
positive regulation of exocytosis
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of voltage-gated chloride channel activity
respiratory gaseous exchange
small GTPase mediated signal transduction
sperm capacitation
transmembrane transport
transport
vesicle docking involved in exocytosis - Gene Ontology Biological Process:
- cellular response to cAMP
chloride transmembrane transport
cholesterol biosynthetic process
cholesterol transport
intracellular pH elevation
membrane hyperpolarization
positive regulation of cyclic nucleotide-gated ion channel activity
positive regulation of exocytosis
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of voltage-gated chloride channel activity
respiratory gaseous exchange
small GTPase mediated signal transduction
sperm capacitation
transmembrane transport
transport
vesicle docking involved in exocytosis - Gene Ontology Molecular Function:
- ATP binding
ATP-binding and phosphorylation-dependent chloride channel activity
bicarbonate transmembrane transporter activity
channel-conductance-controlling ATPase activity
chloride channel activity
chloride channel inhibitor activity
chloride transmembrane transporter activity
enzyme binding
PDZ domain binding - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
cell surface
chloride channel complex
cytoplasm
cytosol
early endosome
early endosome membrane
extracellular exosome
Golgi-associated vesicle membrane
lysosomal membrane
plasma membrane
protein complex
recycling endosome - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell membrane
Chloride
Chloride channel
Complete proteome
Disease mutation
Endosome
Glycoprotein
Hydrolase
Ion channel
Ion transport
Isopeptide bond
Lipoprotein
Membrane
Nucleotide-binding
Palmitate
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Ubl conjugation - Interacts With:
- P51572; P27824; Q9BUN8; Q9H8Y8; P19120; P05787; Q9HBW0; Q5T2W1; Q99942; Q9QX74; Q96RN1; O14745; Q15599
Publication
- PubMed ID:
- 2475911 1710598 12853948 12690205 1377674 7518437 9385646 10766763 11707463 12403779 12519745 15247260 1378801 12913074 12588899 17462998 19398555 20068231 22178883 22207244 22121115 22119790 24019521 9517543 11304524 1284534 1695717 2236053 1710600 1284466 1284468 1284530 1284529 7680525 7683628 7683954 7505694 7504969 7522211 7513296 7525450 7520022 7524913 7524909 7517264 8081395 7529962 7539342 7544319 8522333 7537150 7541273 7581407 7543567 7541510 8800923 8829633 8723693 8723695 8956039 9067761 9101301 9222768 9375855 9401006 9443874 9521595 9921909 9736778 9482579 9554753 9452048 9452054 9452073 10651488 10094564 18987736