Names & Taxonomy
- Uniprot ID:
- P12724
- Entry Name:
- ECP_HUMAN
- Status:
- reviewed
- Protein Names:
- Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3)
- Gene Names:
- RNASE3 ECP RNS3
- Gene Names Primary:
- RNASE3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 160
- Sequence:
- MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
Function
- Function:
- Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
- Active Site:
- ACT_SITE 42 42 Proton acceptor.; ACT_SITE 155 155 Proton donor.
- Cross Reference Drug Bank:
- DB01411
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
endonuclease activity
nucleic acid binding
ribonuclease activity
antibacterial humoral response
defense response to Gram-positive bacterium
innate immune response in mucosa
nucleic acid phosphodiester bond hydrolysis
RNA catabolic process
RNA phosphodiester bond hydrolysis - Gene Ontology Biological Process:
- antibacterial humoral response
defense response to Gram-positive bacterium
innate immune response in mucosa
nucleic acid phosphodiester bond hydrolysis
RNA catabolic process
RNA phosphodiester bond hydrolysis - Gene Ontology Molecular Function:
- endonuclease activity
nucleic acid binding
ribonuclease activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space - Keywords:
- 3D-structure
Antibiotic
Antimicrobial
Complete proteome
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Hydrolase
Nitration
Nuclease
Polymorphism
Reference proteome
Secreted
Signal