Names & Taxonomy
- Uniprot ID:
- P12532
- Entry Name:
- KCRU_HUMAN
- Status:
- reviewed
- Protein Names:
- Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK)
- Gene Names:
- CKMT1A CKMT; CKMT1B CKMT
- Gene Names Orf:
- ;
- Gene Names Primary:
- CKMT1A; CKMT1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 417
- Sequence:
- MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRPEPVRAASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFADLFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGGVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPTPVIHTKH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Function
- Function:
- Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
- Catalytic Activity:
- ATP + creatine = ADP + phosphocreatine.
- Cross Reference Drug Bank:
- DB00148
- Gene Ontology Go:
- extracellular exosome
mitochondrial inner membrane
mitochondrion
ATP binding
creatine kinase activity
cellular nitrogen compound metabolic process
creatine metabolic process
polyamine metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
creatine metabolic process
polyamine metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
creatine kinase activity - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial inner membrane
mitochondrion - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Kinase
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase
Transit peptide