Names & Taxonomy
- Uniprot ID:
- P12277
- Entry Name:
- KCRB_HUMAN
- Status:
- reviewed
- Protein Names:
- Creatine kinase B-type (EC 2.7.3.2) (B-CK) (Creatine kinase B chain)
- Gene Names:
- CKB CKBB
- Gene Names Primary:
- CKB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 381
- Sequence:
- MPFSNSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRAKSTPSGFTLDDVIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKPSDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKDYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPNLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
- Catalytic Activity:
- ATP + creatine = ADP + phosphocreatine.
- Cross Reference Drug Bank:
- DB00148
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
extracellular space
mitochondrion
myelin sheath
ATP binding
creatine kinase activity
ubiquitin protein ligase binding
cellular chloride ion homeostasis
cellular nitrogen compound metabolic process
creatine metabolic process
polyamine metabolic process
small molecule metabolic process
substantia nigra development - Gene Ontology Biological Process:
- cellular chloride ion homeostasis
cellular nitrogen compound metabolic process
creatine metabolic process
polyamine metabolic process
small molecule metabolic process
substantia nigra development - Gene Ontology Molecular Function:
- ATP binding
creatine kinase activity
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
extracellular space
mitochondrion
myelin sheath - Keywords:
- 3D-structure
ATP-binding
Complete proteome
Cytoplasm
Direct protein sequencing
Kinase
Nitration
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- Q03463; Q96DX5