Names & Taxonomy
- Uniprot ID:
- P12259
- Entry Name:
- FA5_HUMAN
- Status:
- reviewed
- Protein Names:
- Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]
- Gene Names:
- F5
- Gene Names Primary:
- F5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2224
- Sequence:
- MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAPSHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGSPSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRLKKSQFLIKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPSMDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPSSPTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMKKSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDIY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by SERPINA5.
- Cross Reference Drug Bank:
- DB05777 DB00055
- Gene Ontology Go:
- endoplasmic reticulum lumen
endoplasmic reticulum-Golgi intermediate compartment membrane
ER to Golgi transport vesicle
extracellular region
extracellular space
extracellular vesicle
Golgi membrane
membrane
plasma membrane
platelet alpha granule lumen
copper ion binding
blood circulation
blood coagulation
cellular protein metabolic process
COPII vesicle coating
ER to Golgi vesicle-mediated transport
membrane organization
platelet activation
platelet degranulation
post-translational protein modification
protein N-linked glycosylation via asparagine - Gene Ontology Biological Process:
- blood circulation
blood coagulation
cellular protein metabolic process
COPII vesicle coating
ER to Golgi vesicle-mediated transport
membrane organization
platelet activation
platelet degranulation
post-translational protein modification
protein N-linked glycosylation via asparagine - Gene Ontology Molecular Function:
- copper ion binding
- Gene Ontology Cellular Component:
- endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum lumen
ER to Golgi transport vesicle
extracellular region
extracellular space
extracellular vesicle
Golgi membrane
membrane
plasma membrane
platelet alpha granule lumen - Keywords:
- 3D-structure
Blood coagulation
Calcium
Complete proteome
Copper
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Sulfation
Thrombophilia
Zymogen
Publication
- PubMed ID:
- 3110773 1567832 16710414 14702039 2827731 11758222 3092220 8454869 6323392 6490642 2844223 8204629 2168225 7989361 8665956 9556620 11018168 15140131 16335952 16263699 18088087 19690332 26091039 10586886 7874144 8164741 8713778 9245936 9454741 9454742 9746807 10391209 10942390 11435304 11858490 12393490 14617013 15534175 14695241 16959974