Names & Taxonomy

Uniprot ID:
P11926
Entry Name:
DCOR_HUMAN
Status:
reviewed
Protein Names:
Ornithine decarboxylase (ODC) (EC 4.1.1.17)
Gene Names:
ODC1
Gene Names Primary:
ODC1
Organism:
Homo sapiens (Human)

Structure

Length:
461
Sequence:
MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV
Proteomes:
UP000005640

Function

Function:
Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.
Pathway:
Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Catalytic Activity:
L-ornithine = putrescine + CO(2).
Cofactor:
COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Enzyme Regulation:
ENZYME REGULATION: Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3.
Active Site:
ACT_SITE 360 360 Proton donor; shared with dimeric partner.
Cross Reference Drug Bank:
DB06243 DB00127
Gene Ontology Go:
cytoplasm
cytosol
perinuclear region of cytoplasm
ornithine decarboxylase activity
protein homodimerization activity
cellular nitrogen compound metabolic process
kidney development
polyamine metabolic process
positive regulation of cell proliferation
putrescine biosynthetic process from ornithine
regulation of cellular amino acid metabolic process
regulation of protein catabolic process
response to virus
small molecule metabolic process
Gene Ontology Biological Process:
cellular nitrogen compound metabolic process
kidney development
polyamine metabolic process
positive regulation of cell proliferation
putrescine biosynthetic process from ornithine
regulation of cellular amino acid metabolic process
regulation of protein catabolic process
response to virus
small molecule metabolic process
Gene Ontology Molecular Function:
ornithine decarboxylase activity
protein homodimerization activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
perinuclear region of cytoplasm
Keywords:
3D-structure
Complete proteome
Decarboxylase
Lyase
Phosphoprotein
Polyamine biosynthesis
Pyridoxal phosphate
Reference proteome
S-nitrosylation
Interacts With:
Q9H8Y8; Q92993; Q9UMX2

Publication

PubMed ID:
3595418 2693021 2587220 2227439 2318872 1598217 8519686 14702039 15815621 15489334 2317811 3308908 10462479 11461922 16548883 17900240 10623504