Names & Taxonomy
- Uniprot ID:
- P11926
- Entry Name:
- DCOR_HUMAN
- Status:
- reviewed
- Protein Names:
- Ornithine decarboxylase (ODC) (EC 4.1.1.17)
- Gene Names:
- ODC1
- Gene Names Primary:
- ODC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 461
- Sequence:
- MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV
- Proteomes:
- UP000005640
Function
- Function:
- Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.
- Pathway:
- Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
- Catalytic Activity:
- L-ornithine = putrescine + CO(2).
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3.
- Active Site:
- ACT_SITE 360 360 Proton donor; shared with dimeric partner.
- Cross Reference Drug Bank:
- DB06243 DB00127
- Gene Ontology Go:
- cytoplasm
cytosol
perinuclear region of cytoplasm
ornithine decarboxylase activity
protein homodimerization activity
cellular nitrogen compound metabolic process
kidney development
polyamine metabolic process
positive regulation of cell proliferation
putrescine biosynthetic process from ornithine
regulation of cellular amino acid metabolic process
regulation of protein catabolic process
response to virus
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
kidney development
polyamine metabolic process
positive regulation of cell proliferation
putrescine biosynthetic process from ornithine
regulation of cellular amino acid metabolic process
regulation of protein catabolic process
response to virus
small molecule metabolic process - Gene Ontology Molecular Function:
- ornithine decarboxylase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
perinuclear region of cytoplasm - Keywords:
- 3D-structure
Complete proteome
Decarboxylase
Lyase
Phosphoprotein
Polyamine biosynthesis
Pyridoxal phosphate
Reference proteome
S-nitrosylation - Interacts With:
- Q9H8Y8; Q92993; Q9UMX2