Names & Taxonomy
- Uniprot ID:
- P11310
- Entry Name:
- ACADM_HUMAN
- Status:
- reviewed
- Protein Names:
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7)
- Gene Names:
- ACADM
- Gene Names Primary:
- ACADM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 421
- Sequence:
- MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
- Pathway:
- Lipid metabolism; mitochondrial fatty acid beta-oxidation.
- Catalytic Activity:
- A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Active Site:
- ACT_SITE 401 401 Proton acceptor.
- Cross Reference Drug Bank:
- DB03147
- Gene Ontology Go:
- axon
extracellular exosome
mitochondrial matrix
mitochondrion
nucleus
acyl-CoA dehydrogenase activity
electron carrier activity
fatty-acyl-CoA binding
flavin adenine dinucleotide binding
identical protein binding
medium-chain-acyl-CoA dehydrogenase activity
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
carnitine biosynthetic process
carnitine metabolic process, CoA-linked
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
lipid homeostasis
medium-chain fatty acid catabolic process
medium-chain fatty acid metabolic process
oxidation-reduction process
small molecule metabolic process - Gene Ontology Biological Process:
- carnitine biosynthetic process
carnitine metabolic process, CoA-linked
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
lipid homeostasis
medium-chain fatty acid catabolic process
medium-chain fatty acid metabolic process
oxidation-reduction process
small molecule metabolic process - Gene Ontology Molecular Function:
- acyl-CoA dehydrogenase activity
electron carrier activity
fatty-acyl-CoA binding
flavin adenine dinucleotide binding
identical protein binding
medium-chain-acyl-CoA dehydrogenase activity
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor - Gene Ontology Cellular Component:
- axon
extracellular exosome
mitochondrial matrix
mitochondrion
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
FAD
Fatty acid metabolism
Flavoprotein
Lipid metabolism
Mitochondrion
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide