Names & Taxonomy

Uniprot ID:
P11245
Entry Name:
ARY2_HUMAN
Status:
reviewed
Protein Names:
Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (N-acetyltransferase type 2) (NAT-2) (Polymorphic arylamine N-acetyltransferase) (PNAT)
Gene Names:
NAT2 AAC2
Gene Names Primary:
NAT2
Organism:
Homo sapiens (Human)

Structure

Length:
290
Sequence:
MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENLNMHCGQAMELGLEAIFDHIVRRNRGGWCLQVNQLLYWALTTIGFQTTMLGGYFYIPPVNKYSTGMVHLLLQVTIDGRNYIVDAGSGSSSQMWQPLELISGKDQPQVPCIFCLTEERGIWYLDQIRREQYITNKEFLNSHLLPKKKHQKIYLFTLEPRTIEDFESMNTYLQTSPTSSFITTSFCSLQTPEGVYCLVGFILTYRKFNYKDNTDLVEFKTLTEEEVEEVLKNIFKISLGRNLVPKPGDGSLTI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Catalytic Activity:
Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Active Site:
ACT_SITE 68 68 Acyl-thioester intermediate.; ACT_SITE 107 107; ACT_SITE 122 122
Cross Reference Drug Bank:
DB00316 DB01068 DB00250 DB04953 DB00951 DB01015
Gene Ontology Go:
cytosol
arylamine N-acetyltransferase activity
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
arylamine N-acetyltransferase activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Acyltransferase
Complete proteome
Cytoplasm
Direct protein sequencing
Polymorphism
Reference proteome
Transferase
Interacts With:
Q13315; Q06609

Publication

PubMed ID:
2734109 2340091 1968463 1381364 7915226 16416399 16421571 15489334 1676262 2924904 17656365 2068113 8466518 7920692