Names & Taxonomy
- Uniprot ID:
- P11172
- Entry Name:
- UMPS_HUMAN
- Status:
- reviewed
- Protein Names:
- Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (EC 4.1.1.23) (OMPdecase)]
- Gene Names:
- UMPS OK/SW-cl.21
- Gene Names Orf:
- OK/SW-cl.21
- Gene Names Primary:
- UMPS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 480
- Sequence:
- MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
- Proteomes:
- UP000005640
Function
- Pathway:
- Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
- Catalytic Activity:
- Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.; Orotidine 5'-phosphate = UMP + CO(2).
- Active Site:
- ACT_SITE 312 312 For OMPdecase activity.
- Cross Reference Drug Bank:
- DB00544
- Gene Ontology Go:
- cytoplasm
cytosol
nucleus
orotate phosphoribosyltransferase activity
orotidine-5'-phosphate decarboxylase activity
'de novo' pyrimidine nucleobase biosynthetic process
'de novo' UMP biosynthetic process
cellular response to drug
female pregnancy
lactation
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
small molecule metabolic process
UMP biosynthetic process - Gene Ontology Biological Process:
- 'de novo' pyrimidine nucleobase biosynthetic process
'de novo' UMP biosynthetic process
cellular response to drug
female pregnancy
lactation
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
small molecule metabolic process
UMP biosynthetic process - Gene Ontology Molecular Function:
- orotate phosphoribosyltransferase activity
orotidine-5'-phosphate decarboxylase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Decarboxylase
Disease mutation
Glycosyltransferase
Lyase
Multifunctional enzyme
Phosphoprotein
Polymorphism
Pyrimidine biosynthesis
Reference proteome
Transferase