Names & Taxonomy

Uniprot ID:
P11169
Entry Name:
GTR3_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3)
Gene Names:
SLC2A3 GLUT3
Gene Names Primary:
SLC2A3
Organism:
Homo sapiens (Human)

Structure

Length:
496
Sequence:
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).
Gene Ontology Go:
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
glucose binding
glucose transmembrane transporter activity
carbohydrate metabolic process
glucose transmembrane transport
glucose transport
hexose transport
L-ascorbic acid metabolic process
small molecule metabolic process
transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
glucose transmembrane transport
glucose transport
hexose transport
L-ascorbic acid metabolic process
small molecule metabolic process
transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Molecular Function:
glucose binding
glucose transmembrane transporter activity
Gene Ontology Cellular Component:
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
Keywords:
3D-structure
Cell membrane
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
3170580 14702039 15489334 9477959 26176916