Names & Taxonomy
- Uniprot ID:
- P11169
- Entry Name:
- GTR3_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3)
- Gene Names:
- SLC2A3 GLUT3
- Gene Names Primary:
- SLC2A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 496
- Sequence:
- MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).
- Gene Ontology Go:
- extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
glucose binding
glucose transmembrane transporter activity
carbohydrate metabolic process
glucose transmembrane transport
glucose transport
hexose transport
L-ascorbic acid metabolic process
small molecule metabolic process
transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
glucose transmembrane transport
glucose transport
hexose transport
L-ascorbic acid metabolic process
small molecule metabolic process
transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- glucose binding
glucose transmembrane transporter activity - Gene Ontology Cellular Component:
- extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix
Transport