Names & Taxonomy
- Uniprot ID:
- P11021
- Entry Name:
- GRP78_HUMAN
- Status:
- reviewed
- Protein Names:
- 78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)
- Gene Names:
- HSPA5 GRP78
- Gene Names Primary:
- HSPA5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 654
- Sequence:
- MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum lumen. Melanosome. Cytoplasm
Function
- Function:
- Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.
- Cross Reference Drug Bank:
- DB00945 DB00025
- Gene Ontology Go:
- cell surface
endoplasmic reticulum
endoplasmic reticulum chaperone complex
endoplasmic reticulum lumen
endoplasmic reticulum membrane
endoplasmic reticulum-Golgi intermediate compartment
extracellular exosome
focal adhesion
integral component of endoplasmic reticulum membrane
melanosome
membrane
midbody
mitochondrion
myelin sheath
nucleus
plasma membrane
smooth endoplasmic reticulum
ATP binding
ATPase activity
calcium ion binding
chaperone binding
enzyme binding
glycoprotein binding
misfolded protein binding
protein domain specific binding
ribosome binding
ubiquitin protein ligase binding
unfolded protein binding
activation of signaling protein activity involved in unfolded protein response
ATF6-mediated unfolded protein response
blood coagulation
cellular protein metabolic process
cellular response to antibiotic
cellular response to glucose starvation
cellular response to interleukin-4
cellular response to manganese ion
cerebellar Purkinje cell layer development
cerebellum structural organization
endoplasmic reticulum unfolded protein response
ER overload response
ER-associated ubiquitin-dependent protein catabolic process
IRE1-mediated unfolded protein response
maintenance of protein localization in endoplasmic reticulum
negative regulation of apoptotic process
negative regulation of protein homodimerization activity
negative regulation of transforming growth factor beta receptor signaling pathway
PERK-mediated unfolded protein response
platelet activation
platelet degranulation
positive regulation of cell migration
positive regulation of protein ubiquitination
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
protein folding in endoplasmic reticulum
regulation of ATF6-mediated unfolded protein response
regulation of IRE1-mediated unfolded protein response
regulation of PERK-mediated unfolded protein response
regulation of protein folding in endoplasmic reticulum
substantia nigra development
toxin transport - Gene Ontology Biological Process:
- activation of signaling protein activity involved in unfolded protein response
ATF6-mediated unfolded protein response
blood coagulation
cellular protein metabolic process
cellular response to antibiotic
cellular response to glucose starvation
cellular response to interleukin-4
cellular response to manganese ion
cerebellar Purkinje cell layer development
cerebellum structural organization
endoplasmic reticulum unfolded protein response
ER-associated ubiquitin-dependent protein catabolic process
ER overload response
IRE1-mediated unfolded protein response
maintenance of protein localization in endoplasmic reticulum
negative regulation of apoptotic process
negative regulation of protein homodimerization activity
negative regulation of transforming growth factor beta receptor signaling pathway
PERK-mediated unfolded protein response
platelet activation
platelet degranulation
positive regulation of cell migration
positive regulation of protein ubiquitination
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
protein folding in endoplasmic reticulum
regulation of ATF6-mediated unfolded protein response
regulation of IRE1-mediated unfolded protein response
regulation of PERK-mediated unfolded protein response
regulation of protein folding in endoplasmic reticulum
substantia nigra development
toxin transport - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
calcium ion binding
chaperone binding
enzyme binding
glycoprotein binding
misfolded protein binding
protein domain specific binding
ribosome binding
ubiquitin protein ligase binding
unfolded protein binding - Gene Ontology Cellular Component:
- cell surface
endoplasmic reticulum
endoplasmic reticulum chaperone complex
endoplasmic reticulum-Golgi intermediate compartment
endoplasmic reticulum lumen
endoplasmic reticulum membrane
extracellular exosome
focal adhesion
integral component of endoplasmic reticulum membrane
melanosome
membrane
midbody
mitochondrion
myelin sheath
nucleus
plasma membrane
smooth endoplasmic reticulum - Keywords:
- 3D-structure
ATP-binding
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Endoplasmic reticulum
Isopeptide bond
Methylation
Nitration
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Signal
Ubl conjugation - Interacts With:
- Q6T424; P31749; Q6E0U4; Q9UBS4; Q91YW3; Q96IZ0; Q62627; P04049; P61619