Names & Taxonomy
- Uniprot ID:
- P10809
- Entry Name:
- CH60_HUMAN
- Status:
- reviewed
- Protein Names:
- 60 kDa heat shock protein, mitochondrial (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)
- Gene Names:
- HSPD1 HSP60
- Gene Names Primary:
- HSPD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 573
- Sequence:
- MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
- Gene Ontology Go:
- cell surface
coated pit
coated vesicle
cytoplasm
cytosol
early endosome
extracellular exosome
extracellular space
lipopolysaccharide receptor complex
membrane
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
protein complex
secretory granule
ATP binding
ATPase activity
chaperone binding
DNA replication origin binding
double-stranded RNA binding
lipopolysaccharide binding
p53 binding
poly(A) RNA binding
single-stranded DNA binding
ubiquitin protein ligase binding
unfolded protein binding
'de novo' protein folding
activation of cysteine-type endopeptidase activity involved in apoptotic process
B cell activation
B cell cytokine production
B cell proliferation
chaperone-mediated protein complex assembly
isotype switching to IgG isotypes
MyD88-dependent toll-like receptor signaling pathway
negative regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of interferon-alpha production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of macrophage activation
positive regulation of T cell activation
positive regulation of T cell mediated immune response to tumor cell
protein maturation
protein refolding
protein stabilization
response to cold
response to unfolded protein
T cell activation
viral process - Gene Ontology Biological Process:
- 'de novo' protein folding
activation of cysteine-type endopeptidase activity involved in apoptotic process
B cell activation
B cell cytokine production
B cell proliferation
chaperone-mediated protein complex assembly
isotype switching to IgG isotypes
MyD88-dependent toll-like receptor signaling pathway
negative regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of interferon-alpha production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of macrophage activation
positive regulation of T cell activation
positive regulation of T cell mediated immune response to tumor cell
protein maturation
protein refolding
protein stabilization
response to cold
response to unfolded protein
T cell activation
viral process - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
chaperone binding
DNA replication origin binding
double-stranded RNA binding
lipopolysaccharide binding
p53 binding
poly(A) RNA binding
single-stranded DNA binding
ubiquitin protein ligase binding
unfolded protein binding - Gene Ontology Cellular Component:
- cell surface
coated pit
coated vesicle
cytoplasm
cytosol
early endosome
extracellular exosome
extracellular space
lipopolysaccharide receptor complex
membrane
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
protein complex
secretory granule - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Chaperone
Complete proteome
Direct protein sequencing
Disease mutation
Hereditary spastic paraplegia
Host-virus interaction
Leukodystrophy
Mitochondrion
Neurodegeneration
Nucleotide-binding
Phosphoprotein
Reference proteome
Transit peptide - Interacts With:
- P38398; Q8NHQ1; P49789; Q15323; Q6A162; P60410; P26371; Q9BRK4; Q9Y4C4; Q7Z3S9; O76081; O76081-6; Q8N6K7; Q9JJY3; Q7Z6C6