Names & Taxonomy
- Uniprot ID:
- P10768
- Entry Name:
- ESTD_HUMAN
- Status:
- reviewed
- Protein Names:
- S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56)
- Gene Names:
- ESD
- Gene Names Primary:
- ESD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 282
- Sequence:
- MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQNFISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVLCPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Cytoplasmic vesicle.
Function
- Function:
- Serine hydrolase involved in the detoxification of formaldehyde.
- Catalytic Activity:
- S-formylglutathione + H(2)O = glutathione + formate.
- Active Site:
- ACT_SITE 149 149 Charge relay system.
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytoplasmic, membrane-bounded vesicle
endoplasmic reticulum lumen
extracellular exosome
carboxylic ester hydrolase activity
hydrolase activity, acting on ester bonds
methylumbelliferyl-acetate deacetylase activity
S-formylglutathione hydrolase activity
formaldehyde catabolic process
glutathione derivative biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- formaldehyde catabolic process
glutathione derivative biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- carboxylic ester hydrolase activity
hydrolase activity, acting on ester bonds
methylumbelliferyl-acetate deacetylase activity
S-formylglutathione hydrolase activity - Gene Ontology Cellular Component:
- cytoplasmic, membrane-bounded vesicle
endoplasmic reticulum lumen
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Hydrolase
Polymorphism
Reference proteome
Serine esterase - Interacts With:
- A1L4K1