Names & Taxonomy
- Uniprot ID:
- P10646
- Entry Name:
- TFPI1_HUMAN
- Status:
- reviewed
- Protein Names:
- Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI)
- Gene Names:
- TFPI LACI TFPI1
- Gene Names Primary:
- TFPI
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 304
- Sequence:
- MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Alpha: Secreted.; Isoform Beta: Microsome membrane
Function
- Function:
- Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
- Cross Reference Drug Bank:
- DB00036 DB06779
- Gene Ontology Go:
- anchored component of membrane
cell surface
endoplasmic reticulum
extracellular region
extracellular space
organelle membrane
plasma membrane
endopeptidase inhibitor activity
serine-type endopeptidase inhibitor activity
blood coagulation
blood coagulation, extrinsic pathway
negative regulation of endopeptidase activity - Gene Ontology Biological Process:
- blood coagulation
blood coagulation, extrinsic pathway
negative regulation of endopeptidase activity - Gene Ontology Molecular Function:
- endopeptidase inhibitor activity
serine-type endopeptidase inhibitor activity - Gene Ontology Cellular Component:
- anchored component of membrane
cell surface
endoplasmic reticulum
extracellular region
extracellular space
organelle membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Blood coagulation
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
GPI-anchor
Glycoprotein
Hemostasis
Lipoprotein
Membrane
Microsome
Polymorphism
Protease inhibitor
Reference proteome
Repeat
Secreted
Serine protease inhibitor
Signal