Names & Taxonomy
- Uniprot ID:
- P10636
- Entry Name:
- TAU_HUMAN
- Status:
- reviewed
- Protein Names:
- Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
- Gene Names:
- MAPT MAPTL MTBT1 TAU
- Gene Names Primary:
- MAPT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 758
- Sequence:
- MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
- Cross Reference Drug Bank:
- DB01248 DB01229
- Gene Ontology Go:
- axon
axoneme
cell body
cytoplasmic ribonucleoprotein granule
cytosol
dendrite
growth cone
microtubule
microtubule associated complex
neurofibrillary tangle
nuclear periphery
plasma membrane
postsynaptic density
tubulin complex
apolipoprotein binding
enzyme binding
lipoprotein particle binding
microtubule binding
SH3 domain binding
structural constituent of cytoskeleton
adult walking behavior
apoptotic process
axo-dendritic transport
axon extension
brain development
cellular component disassembly involved in execution phase of apoptosis
female pregnancy
generation of neurons
intrinsic apoptotic signaling pathway in response to oxidative stress
microtubule cytoskeleton organization
mitochondrion transport along microtubule
negative regulation of intracellular transport
neuron migration
neuron projection development
positive regulation of axon extension
positive regulation of microtubule polymerization
programmed cell death
regulation of autophagy
regulation of microtubule polymerization
regulation of microtubule-based movement
response to nutrient
response to organic substance - Gene Ontology Biological Process:
- adult walking behavior
apoptotic process
axo-dendritic transport
axon extension
brain development
cellular component disassembly involved in execution phase of apoptosis
female pregnancy
generation of neurons
intrinsic apoptotic signaling pathway in response to oxidative stress
microtubule cytoskeleton organization
mitochondrion transport along microtubule
negative regulation of intracellular transport
neuron migration
neuron projection development
positive regulation of axon extension
positive regulation of microtubule polymerization
programmed cell death
regulation of autophagy
regulation of microtubule-based movement
regulation of microtubule polymerization
response to nutrient
response to organic substance - Gene Ontology Molecular Function:
- apolipoprotein binding
enzyme binding
lipoprotein particle binding
microtubule binding
SH3 domain binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- axon
axoneme
cell body
cytoplasmic ribonucleoprotein granule
cytosol
dendrite
growth cone
microtubule
microtubule associated complex
neurofibrillary tangle
nuclear periphery
plasma membrane
postsynaptic density
tubulin complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Alzheimer disease
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Disulfide bond
Glycation
Glycoprotein
Isopeptide bond
Membrane
Microtubule
Neurodegeneration
Parkinsonism
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Ubl conjugation - Interacts With:
- P02649; P05067; O00499-1; Q14203; P49841; P08238; Q5S007; Q7KZI7; P04156; P43004; P37840; Q9UNE7; P63104
Publication
- PubMed ID:
- 3131773 2498079 2516729 2484340 1420178 16625196 15489334 1512244 16443603 7706316 2495000 1899488 1915258 15365985 1713721 8999860 9326300 9735171 9614189 10747907 14761950 14690523 14999081 15953362 15546861 16923168 16982696 16964243 17562708 18599021 18220336 19413330 19451179 19542233 19690332 20068231 21327254 21985311 23666762 24275569 11313338 10899436 9629852 9736786 9641683 9789048 10412802 9973279 10553987 10214944 10374757 10604746 10489057 10534245 10208578 11117541 11117542 11089577 10802785 11071507 11585254 11220749 11601501 11278002 12473774 11891833 11921059 12325083 11906000 11889249 12509859 14595660 14517953 14991829 14991828 16240366 16157753 15883319 20020531 26086902