Names & Taxonomy
- Uniprot ID:
- P10632
- Entry Name:
- CP2C8_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase)
- Gene Names:
- CYP2C8
- Gene Names Primary:
- CYP2C8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 490
- Sequence:
- MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
- Catalytic Activity:
- RH + + O(2) = ROH + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.18 uM for paclitaxel
- Cross Reference Drug Bank:
- DB05812 DB00316 DB00945 DB00918 DB01424 DB01118 DB00321 DB00381 DB00613 DB00701 DB01435 DB06605 DB01076 DB00972 DB06770 DB01393 DB00188 DB00835 DB00921 DB01156 DB06772 DB00201 DB00796 DB00564 DB00748 DB00446 DB00608 DB00169 DB00501 DB00604 DB00758 DB00257 DB00363 DB00907 DB01394 DB00531 DB00091 DB08912 DB00250 DB00705 DB01234 DB00514 DB00647 DB00829 DB00586 DB00255 DB00343 DB01184 DB06210 DB08899 DB00530 DB00783 DB00402 DB00977 DB00773 DB01023 DB01039 DB00544 DB01095 DB01320 DB01241 DB01218 DB00741 DB01050 DB09054 DB01181 DB01029 DB00951 DB09570 DB01221 DB06738 DB01026 DB01009 DB00448 DB01259 DB08918 DB00451 DB00281 DB01583 DB00836 DB00455 DB00678 DB00227 DB00603 DB00784 DB00814 DB00333 DB00916 DB00370 DB00764 DB00471 DB00295 DB00688 DB01183 DB00788 DB00622 DB00184 DB01115 DB04868 DB00665 DB06712 DB09080 DB00338 DB01062 DB01229 DB00617 DB00715 DB06589 DB00738 DB00850 DB00780 DB01174 DB00946 DB00252 DB01132 DB00554 DB08860 DB08901 DB00175 DB00794 DB01032 DB00396 DB01182 DB00818 DB00205 DB00908 DB00468 DB00481 DB08896 DB00912 DB01045 DB01201 DB00503 DB00412 DB00938 DB01232 DB00418 DB01037 DB11362 DB00641 DB01261 DB00398 DB00421 DB00359 DB01015 DB06729 DB01138 DB00675 DB00799 DB00231 DB00857 DB00624 DB00277 DB00679 DB00208 DB01007 DB01124 DB00214 DB08911 DB00755 DB00897 DB00347 DB00440 DB01361 DB00313 DB00661 DB08828 DB09068 DB00682 DB00549 DB00495 DB01198
- Gene Ontology Go:
- endoplasmic reticulum membrane
arachidonic acid epoxygenase activity
aromatase activity
caffeine oxidase activity
heme binding
iron ion binding
monooxygenase activity
steroid hydroxylase activity
arachidonic acid metabolic process
drug metabolic process
epoxygenase P450 pathway
exogenous drug catabolic process
omega-hydroxylase P450 pathway
organic acid metabolic process
oxidation-reduction process
oxidative demethylation
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
drug metabolic process
epoxygenase P450 pathway
exogenous drug catabolic process
omega-hydroxylase P450 pathway
organic acid metabolic process
oxidation-reduction process
oxidative demethylation
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- arachidonic acid epoxygenase activity
aromatase activity
caffeine oxidase activity
heme binding
iron ion binding
monooxygenase activity
steroid hydroxylase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome