Names & Taxonomy
- Uniprot ID:
- P10600
- Entry Name:
- TGFB3_HUMAN
- Status:
- reviewed
- Protein Names:
- Transforming growth factor beta-3 (TGF-beta-3) [Cleaved into: Latency-associated peptide (LAP)]
- Gene Names:
- TGFB3
- Gene Names Primary:
- TGFB3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 412
- Sequence:
- MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Involved in embryogenesis and cell differentiation.
- Gene Ontology Go:
- cell surface
extracellular matrix
extracellular region
extracellular space
neuronal cell body
nucleus
plasma membrane
platelet alpha granule lumen
T-tubule
cytokine activity
identical protein binding
transforming growth factor beta binding
type I transforming growth factor beta receptor binding
type II transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
activation of MAPK activity
aging
blood coagulation
cell development
cell growth
cell-cell junction organization
detection of hypoxia
digestive tract development
embryonic neurocranium morphogenesis
extracellular matrix organization
face morphogenesis
female pregnancy
frontal suture morphogenesis
in utero embryonic development
inner ear development
lung alveolus development
mammary gland development
negative regulation of cell proliferation
negative regulation of DNA replication
negative regulation of macrophage cytokine production
negative regulation of neuron apoptotic process
negative regulation of transforming growth factor beta receptor signaling pathway
odontogenesis
ossification involved in bone remodeling
palate development
platelet activation
platelet degranulation
positive regulation of apoptotic process
positive regulation of bone mineralization
positive regulation of cell division
positive regulation of collagen biosynthetic process
positive regulation of DNA replication
positive regulation of epithelial to mesenchymal transition
positive regulation of filopodium assembly
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of protein secretion
positive regulation of SMAD protein import into nucleus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of apoptotic process
regulation of cell proliferation
regulation of MAPK cascade
response to estrogen
response to hypoxia
response to laminar fluid shear stress
response to progesterone
salivary gland morphogenesis
SMAD protein import into nucleus
SMAD protein signal transduction
transforming growth factor beta receptor signaling pathway
uterine wall breakdown - Gene Ontology Biological Process:
- activation of MAPK activity
aging
blood coagulation
cell-cell junction organization
cell development
cell growth
detection of hypoxia
digestive tract development
embryonic neurocranium morphogenesis
extracellular matrix organization
face morphogenesis
female pregnancy
frontal suture morphogenesis
inner ear development
in utero embryonic development
lung alveolus development
mammary gland development
negative regulation of cell proliferation
negative regulation of DNA replication
negative regulation of macrophage cytokine production
negative regulation of neuron apoptotic process
negative regulation of transforming growth factor beta receptor signaling pathway
odontogenesis
ossification involved in bone remodeling
palate development
platelet activation
platelet degranulation
positive regulation of apoptotic process
positive regulation of bone mineralization
positive regulation of cell division
positive regulation of collagen biosynthetic process
positive regulation of DNA replication
positive regulation of epithelial to mesenchymal transition
positive regulation of filopodium assembly
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of protein secretion
positive regulation of SMAD protein import into nucleus
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of apoptotic process
regulation of cell proliferation
regulation of MAPK cascade
response to estrogen
response to hypoxia
response to laminar fluid shear stress
response to progesterone
salivary gland morphogenesis
SMAD protein import into nucleus
SMAD protein signal transduction
transforming growth factor beta receptor signaling pathway
uterine wall breakdown - Gene Ontology Molecular Function:
- cytokine activity
identical protein binding
transforming growth factor beta binding
type III transforming growth factor beta receptor binding
type II transforming growth factor beta receptor binding
type I transforming growth factor beta receptor binding - Gene Ontology Cellular Component:
- cell surface
extracellular matrix
extracellular region
extracellular space
neuronal cell body
nucleus
plasma membrane
platelet alpha granule lumen
T-tubule - Keywords:
- 3D-structure
Alternative splicing
Cardiomyopathy
Cleavage on pair of basic residues
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Growth factor
Mitogen
Polymorphism
Reference proteome
Secreted
Signal - Interacts With:
- P37173