Names & Taxonomy
- Uniprot ID:
- P10275
- Entry Name:
- ANDR_HUMAN
- Status:
- reviewed
- Protein Names:
- Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
- Gene Names:
- AR DHTR NR3C4
- Gene Names Primary:
- AR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 920
- Sequence:
- MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
- Enzyme Regulation:
- ENZYME REGULATION: AIM-100 (4-amino-5,6-biaryl-furopyrimidine) suppresses TNK2-mediated phosphorylation at Tyr-269. Inhibits the binding of the Tyr-269 phosphorylated form to androgen-responsive enhancers (AREs) and its transcriptional activity.
- Cross Reference Drug Bank:
- DB01128 DB04839 DB01406 DB01395 DB00858 DB08899 DB00687 DB01185 DB00499 DB01026 DB00367 DB06710 DB08804 DB00984 DB00665 DB00621 DB06412 DB00421 DB00624 DB01420 DB08867
- Gene Ontology Go:
- cytoplasm
cytosol
nuclear chromatin
nucleoplasm
nucleus
protein complex
androgen binding
androgen receptor activity
ATPase binding
beta-catenin binding
chromatin binding
DNA binding
enzyme binding
protein dimerization activity
receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding
androgen receptor signaling pathway
cell growth
cell proliferation
cell-cell signaling
gene expression
intracellular receptor signaling pathway
negative regulation of cell proliferation
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of integrin biosynthetic process
positive regulation of cell differentiation
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of integrin biosynthetic process
positive regulation of NF-kappaB transcription factor activity
positive regulation of phosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
positive regulation of transcription, DNA-templated
prostate gland development
protein oligomerization
regulation of establishment of protein localization to plasma membrane
sex differentiation
signal transduction
small GTPase mediated signal transduction
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
transport - Gene Ontology Biological Process:
- androgen receptor signaling pathway
cell-cell signaling
cell growth
cell proliferation
gene expression
intracellular receptor signaling pathway
negative regulation of cell proliferation
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of integrin biosynthetic process
positive regulation of cell differentiation
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of integrin biosynthetic process
positive regulation of NF-kappaB transcription factor activity
positive regulation of phosphorylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase III promoter
positive regulation of transcription from RNA polymerase II promoter
prostate gland development
protein oligomerization
regulation of establishment of protein localization to plasma membrane
sex differentiation
signal transduction
small GTPase mediated signal transduction
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
transport - Gene Ontology Molecular Function:
- androgen binding
androgen receptor activity
ATPase binding
beta-catenin binding
chromatin binding
DNA binding
enzyme binding
protein dimerization activity
receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nuclear chromatin
nucleoplasm
nucleus
protein complex - Keywords:
- 3D-structure
Activator
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Disease mutation
Isopeptide bond
Lipid-binding
Lipoprotein
Metal-binding
Neurodegeneration
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Pseudohermaphroditism
Receptor
Reference proteome
Steroid-binding
Transcription
Transcription regulation
Triplet repeat expansion
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- P00519; P51451; Q8WV28; P78543; O89110; Q92793; O14595; P35222; Q9UER7; P20711; P11308; P07332; P09769; O75593; Q9R1E0; Q14451; P56524; Q16665; Q16666; O15357; Q15652; P17535; O95251; P07288; P06239; P07948; P20794; P42679; Q00987; Q15596; Q14686; Q99497; P27986; O00459; Q92569; P19174; P16885; Q06830; Q06124; P20936; Q9UBS8; Q9Y252; O14796; Q9NP31; P29353; Q6S5L8; Q5VZ18; Q06986; Q15797; O14544; P12931; Q9ULZ2; P63165; Q9HBL0; O96028; P07947
Publication
- PubMed ID:
- 3216866 3174628 2911578 2594783 2342476 2293020 15634333 19244107 15772651 15489334 2917688 3353726 3377788 2546571 8413310 3353727 1775137 1561105 9096391 10332029 10075738 10383460 10400640 10625666 10930412 11121022 12361945 12039962 12415108 14609956 12958311 14664718 12612053 14573606 16027218 16051670 17045208 16951154 17587566 17550981 18222118 17494760 18451177 18451096 18084323 19909775 19345326 20980437 20501646 20623637 21512132 22170608 21406692 22031296 23887938 24275569 10840043 11906285 15525515 15563469 16129672 16641486 18007036 17311914 17591767 17711855 17911242 1458719 8339746 8240973 7937057 7626493 9016528 22334387 2260966 2082179 1856263 1999491 2010552 2062380 1609793 1424203 1426313 1487249 1307250 1569163 1464650 1430233 1562539 1316540 1480178 1303262 1631125 8213813 8224266 8103398 8281139 8281140 8325932 8325950 8097257 8096390 8274409 8446106 8145761 7511268 8292051 8187068 7910529 7909256 8205256 8033918 8162033 7981687 7981689 8126121 7962294 8040309 7929841 7993455 7970939 8830623 7712463 7641413 7671849 7633398 7537149 7581399 7591265 7673412 8530589 7649358 7723794 8723113 9816170 9039340 9001799 8824883 8550758 8626869 8768864 8823308 8918984 8683794 8647313 8809734 8628719 8827083 9106550 9000575 9196614 9160185 9007482 8990010 9438000 9184448 9255042 9329414 9252933 9328206 9302173 9544375 9698822 9788719 9610419 9856504 9554754 9554755 9543136 9768671 9851768 9627582 9607727 10470409 10363963 10502786 10571951 10221692 10404311 10022458 10629558 10569618 10543676 10221770 10598582 10590024 10458483 10092153 10706109 10690872 11587068 11231320 11744994 15902657 15851746 16595706