Names & Taxonomy

Uniprot ID:
P10109
Entry Name:
ADX_HUMAN
Status:
reviewed
Protein Names:
Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin)
Gene Names:
FDX1 ADX
Gene Names Primary:
FDX1
Organism:
Homo sapiens (Human)

Structure

Length:
184
Sequence:
MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARARSSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDVGKTS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix

Function

Function:
Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.
Cofactor:
COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49601;
Cross Reference Drug Bank:
DB00648
Gene Ontology Go:
mitochondrial matrix
mitochondrion
2 iron, 2 sulfur cluster binding
electron carrier activity
iron ion binding
C21-steroid hormone biosynthetic process
cholesterol metabolic process
hormone biosynthetic process
oxidation-reduction process
small molecule metabolic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
C21-steroid hormone biosynthetic process
cholesterol metabolic process
hormone biosynthetic process
oxidation-reduction process
small molecule metabolic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
2 iron, 2 sulfur cluster binding
electron carrier activity
iron ion binding
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
Keywords:
2Fe-2S
3D-structure
Acetylation
Cholesterol metabolism
Complete proteome
Electron transport
Iron
Iron-sulfur
Lipid metabolism
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Steroid metabolism
Steroidogenesis
Sterol metabolism
Transit peptide
Transport

Publication

PubMed ID:
3229285 3343244 2969697 2340092 15489334 12699818 18669648 20547883 21269460 24275569 25944712 1909889 21636783