Names & Taxonomy
- Uniprot ID:
- P10109
- Entry Name:
- ADX_HUMAN
- Status:
- reviewed
- Protein Names:
- Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin)
- Gene Names:
- FDX1 ADX
- Gene Names Primary:
- FDX1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 184
- Sequence:
- MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARARSSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDVGKTS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Function:
- Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.
- Cofactor:
- COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49601;
- Cross Reference Drug Bank:
- DB00648
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
2 iron, 2 sulfur cluster binding
electron carrier activity
iron ion binding
C21-steroid hormone biosynthetic process
cholesterol metabolic process
hormone biosynthetic process
oxidation-reduction process
small molecule metabolic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- C21-steroid hormone biosynthetic process
cholesterol metabolic process
hormone biosynthetic process
oxidation-reduction process
small molecule metabolic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- 2 iron, 2 sulfur cluster binding
electron carrier activity
iron ion binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- 2Fe-2S
3D-structure
Acetylation
Cholesterol metabolism
Complete proteome
Electron transport
Iron
Iron-sulfur
Lipid metabolism
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Steroid metabolism
Steroidogenesis
Sterol metabolism
Transit peptide
Transport