Names & Taxonomy
- Uniprot ID:
- P0DJD3
- Entry Name:
- RBY1A_HUMAN
- Status:
- reviewed
- Protein Names:
- RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY)
- Gene Names:
- RBMY1A1 RBM1 RBM2 YRRM1 YRRM2
- Gene Names Primary:
- RBMY1A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 496
- Sequence:
- MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.
- Gene Ontology Go:
- nucleus
mRNA binding
nucleotide binding
mRNA processing
regulation of alternative mRNA splicing, via spliceosome
RNA splicing - Gene Ontology Biological Process:
- mRNA processing
regulation of alternative mRNA splicing, via spliceosome
RNA splicing - Gene Ontology Molecular Function:
- mRNA binding
nucleotide binding - Gene Ontology Cellular Component:
- nucleus
- Keywords:
- 3D-structure
Activator
Alternative splicing
Complete proteome
Nucleus
RNA-binding
Reference proteome
mRNA processing
mRNA splicing - Interacts With:
- Q8WTP8; Q9NRW3; Q14781; Q14011; P49761; Q6IBN1; Q8TBB1; Q9Y5E9; F1T0A5; P79522; P98179; P38159; P54274; Q96PQ6