Names & Taxonomy

Uniprot ID:
P0CG47
Entry Name:
UBB_HUMAN
Status:
reviewed
Protein Names:
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene Names:
UBB
Gene Names Primary:
UBB
Organism:
Homo sapiens (Human)

Structure

Length:
229
Sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Ubiquitin: Cytoplasm

Function

Function:
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Gene Ontology Go:
cytosol
endocytic vesicle membrane
endosome membrane
extracellular exosome
extracellular space
mitochondrion
neuron projection
neuronal cell body
nucleoplasm
nucleus
plasma membrane
activation of MAPK activity
activation of MAPKK activity
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
apoptotic process
apoptotic signaling pathway
axon guidance
carbohydrate metabolic process
cell surface receptor signaling pathway
cellular response to hypoxia
circadian rhythm
cytokine-mediated signaling pathway
DNA damage response, detection of DNA damage
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA repair
double-strand break repair
double-strand break repair via homologous recombination
endosomal transport
epidermal growth factor receptor signaling pathway
error-free translesion synthesis
error-prone translesion synthesis
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
gene expression
global genome nucleotide-excision repair
glucose metabolic process
glycogen biosynthetic process
I-kappaB kinase/NF-kappaB signaling
innate immune response
insulin receptor signaling pathway
interstrand cross-link repair
intracellular transport of virus
ion transmembrane transport
JNK cascade
macroautophagy
macromitophagy
MAPK cascade
membrane organization
mitochondrion transport along microtubule
mitotic cell cycle
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
necroptotic process
negative regulation of apoptotic process
negative regulation of canonical Wnt signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of type I interferon production
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
neuron projection morphogenesis
neurotrophin TRK receptor signaling pathway
NIK/NF-kappaB signaling
Notch receptor processing
Notch signaling pathway
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
nucleotide-binding oligomerization domain containing signaling pathway
nucleotide-excision repair
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA gap filling
nucleotide-excision repair, DNA incision
positive regulation of apoptotic process
positive regulation of canonical Wnt signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein monoubiquitination
positive regulation of protein ubiquitination
positive regulation of transcription from RNA polymerase II promoter
positive regulation of type I interferon production
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
programmed cell death
programmed necrotic cell death
protein polyubiquitination
Ras protein signal transduction
regulation of apoptotic process
regulation of mitochondrial membrane potential
regulation of mRNA stability
regulation of necrotic cell death
regulation of neuron death
regulation of proteasomal protein catabolic process
regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of tumor necrosis factor-mediated signaling pathway
regulation of type I interferon production
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
small GTPase mediated signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
stress-activated MAPK cascade
T cell receptor signaling pathway
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
transcription-coupled nucleotide-excision repair
transforming growth factor beta receptor signaling pathway
translesion synthesis
transmembrane transport
TRIF-dependent toll-like receptor signaling pathway
tumor necrosis factor-mediated signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral life cycle
viral process
viral protein processing
virion assembly
Gene Ontology Biological Process:
activation of MAPK activity
activation of MAPKK activity
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
apoptotic process
apoptotic signaling pathway
axon guidance
carbohydrate metabolic process
cell surface receptor signaling pathway
cellular response to hypoxia
circadian rhythm
cytokine-mediated signaling pathway
DNA damage response, detection of DNA damage
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA repair
double-strand break repair
double-strand break repair via homologous recombination
endosomal transport
epidermal growth factor receptor signaling pathway
error-free translesion synthesis
error-prone translesion synthesis
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
gene expression
global genome nucleotide-excision repair
glucose metabolic process
glycogen biosynthetic process
I-kappaB kinase/NF-kappaB signaling
innate immune response
insulin receptor signaling pathway
interstrand cross-link repair
intracellular transport of virus
ion transmembrane transport
JNK cascade
macroautophagy
macromitophagy
MAPK cascade
membrane organization
mitochondrion transport along microtubule
mitotic cell cycle
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
necroptotic process
negative regulation of apoptotic process
negative regulation of canonical Wnt signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of type I interferon production
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
neuron projection morphogenesis
neurotrophin TRK receptor signaling pathway
NIK/NF-kappaB signaling
Notch receptor processing
Notch signaling pathway
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
nucleotide-binding oligomerization domain containing signaling pathway
nucleotide-excision repair
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA gap filling
nucleotide-excision repair, DNA incision
positive regulation of apoptotic process
positive regulation of canonical Wnt signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein monoubiquitination
positive regulation of protein ubiquitination
positive regulation of transcription from RNA polymerase II promoter
positive regulation of type I interferon production
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
programmed cell death
programmed necrotic cell death
protein polyubiquitination
Ras protein signal transduction
regulation of apoptotic process
regulation of mitochondrial membrane potential
regulation of mRNA stability
regulation of necrotic cell death
regulation of neuron death
regulation of proteasomal protein catabolic process
regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of tumor necrosis factor-mediated signaling pathway
regulation of type I interferon production
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
small GTPase mediated signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
stress-activated MAPK cascade
T cell receptor signaling pathway
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
transcription, DNA-templated
transcription-coupled nucleotide-excision repair
transcription initiation from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
translesion synthesis
transmembrane transport
TRIF-dependent toll-like receptor signaling pathway
tumor necrosis factor-mediated signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral life cycle
viral process
viral protein processing
virion assembly
Gene Ontology Cellular Component:
cytosol
endocytic vesicle membrane
endosome membrane
extracellular exosome
extracellular space
mitochondrion
neuronal cell body
neuron projection
nucleoplasm
nucleus
plasma membrane
Keywords:
3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation
Interacts With:
Q8IVM0; P28562; Q9UJY5; Q9NZ52; Q60592; P33993; Q9DLK6; P24610; Q9UJ41; Q9Y3C5; Q68DV7; Q9HAU4

Publication

PubMed ID:
3029682 14745543 16625196 15489334 1128706 16443603 16543144 15466860 17203973 18719106 19754430 21762696 9422699 14597671 24660806 24751536 24784582 25527291