Names & Taxonomy
- Uniprot ID:
- P09960
- Entry Name:
- LKHA4_HUMAN
- Status:
- reviewed
- Protein Names:
- Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase)
- Gene Names:
- LTA4H LTA4
- Gene Names Primary:
- LTA4H
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 611
- Sequence:
- MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
- Pathway:
- Lipid metabolism; leukotriene B4 biosynthesis.
- Catalytic Activity:
- (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by bestatin. Subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379.
- Active Site:
- ACT_SITE 297 297 Proton acceptor.
- Cross Reference Drug Bank:
- DB01197
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
nucleus
plasma membrane
aminopeptidase activity
epoxide hydrolase activity
leukotriene-A4 hydrolase activity
metalloaminopeptidase activity
peptidase activity
peptide binding
poly(A) RNA binding
zinc ion binding
arachidonic acid metabolic process
inflammatory response
leukotriene biosynthetic process
leukotriene metabolic process
peptide catabolic process
response to peptide hormone
response to zinc ion
small molecule metabolic process
Type I pneumocyte differentiation - Gene Ontology Biological Process:
- arachidonic acid metabolic process
inflammatory response
leukotriene biosynthetic process
leukotriene metabolic process
peptide catabolic process
response to peptide hormone
response to zinc ion
small molecule metabolic process
Type I pneumocyte differentiation - Gene Ontology Molecular Function:
- aminopeptidase activity
epoxide hydrolase activity
leukotriene-A4 hydrolase activity
metalloaminopeptidase activity
peptidase activity
peptide binding
poly(A) RNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
nucleus
plasma membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Leukotriene biosynthesis
Metal-binding
Metalloprotease
Phosphoprotein
Polymorphism
Protease
Reference proteome
Zinc - Interacts With:
- Q9BSI4