Names & Taxonomy
- Uniprot ID:
- P09958
- Entry Name:
- FURIN_HUMAN
- Status:
- reviewed
- Protein Names:
- Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)
- Gene Names:
- FURIN FUR PACE PCSK3
- Gene Names Primary:
- FURIN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 794
- Sequence:
- MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
Function
- Function:
- Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
- Catalytic Activity:
- Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Enzyme Regulation:
- ENZYME REGULATION: Could be inhibited by the not secondly cleaved propeptide.
- Active Site:
- ACT_SITE 153 153 Charge relay system.
- Gene Ontology Go:
- cell surface
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
Golgi cisterna
Golgi lumen
Golgi membrane
integral component of membrane
membrane
membrane raft
plasma membrane
trans-Golgi network
trans-Golgi network transport vesicle
endopeptidase activity
metal ion binding
nerve growth factor binding
peptidase activity
peptide binding
protease binding
serine-type endopeptidase activity
serine-type endopeptidase inhibitor activity
aging
cell proliferation
cellular protein metabolic process
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
negative regulation of endopeptidase activity
negative regulation of low-density lipoprotein particle receptor catabolic process
negative regulation of transforming growth factor beta1 production
nerve growth factor processing
nerve growth factor production
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
peptide biosynthetic process
peptide hormone processing
peptidyl-glutamic acid carboxylation
positive regulation of cell migration
positive regulation of membrane protein ectodomain proteolysis
positive regulation of transforming growth factor beta receptor signaling pathway
post-translational protein modification
protein processing
regulation of endopeptidase activity
regulation of low-density lipoprotein particle receptor biosynthetic process
regulation of protein catabolic process
secretion by cell
signal peptide processing
transforming growth factor beta receptor signaling pathway
viral life cycle
viral process
viral protein processing
virion assembly - Gene Ontology Biological Process:
- aging
cell proliferation
cellular protein metabolic process
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
negative regulation of endopeptidase activity
negative regulation of low-density lipoprotein particle receptor catabolic process
negative regulation of transforming growth factor beta1 production
nerve growth factor processing
nerve growth factor production
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
peptide biosynthetic process
peptide hormone processing
peptidyl-glutamic acid carboxylation
positive regulation of cell migration
positive regulation of membrane protein ectodomain proteolysis
positive regulation of transforming growth factor beta receptor signaling pathway
post-translational protein modification
protein processing
regulation of endopeptidase activity
regulation of low-density lipoprotein particle receptor biosynthetic process
regulation of protein catabolic process
secretion by cell
signal peptide processing
transforming growth factor beta receptor signaling pathway
viral life cycle
viral process
viral protein processing
virion assembly - Gene Ontology Molecular Function:
- endopeptidase activity
metal ion binding
nerve growth factor binding
peptidase activity
peptide binding
protease binding
serine-type endopeptidase activity
serine-type endopeptidase inhibitor activity - Gene Ontology Cellular Component:
- cell surface
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
Golgi cisterna
Golgi lumen
Golgi membrane
integral component of membrane
membrane
membrane raft
plasma membrane
trans-Golgi network
trans-Golgi network transport vesicle - Keywords:
- 3D-structure
Autocatalytic cleavage
Calcium
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Glycoprotein
Golgi apparatus
Hydrolase
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Protease
Reference proteome
Serine protease
Signal
Transmembrane
Transmembrane helix
Zymogen - Interacts With:
- O14793