Names & Taxonomy
- Uniprot ID:
- P09651
- Entry Name:
- ROA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
- Gene Names:
- HNRNPA1 HNRPA1
- Gene Names Primary:
- HNRNPA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 372
- Sequence:
- MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.
Function
- Function:
- Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.
- Gene Ontology Go:
- catalytic step 2 spliceosome
cytoplasm
extracellular exosome
intracellular ribonucleoprotein complex
membrane
nucleoplasm
nucleus
spliceosomal complex
G-rich strand telomeric DNA binding
nucleotide binding
poly(A) RNA binding
RNA binding
single-stranded DNA binding
single-stranded RNA binding
telomeric repeat-containing RNA binding
gene expression
mRNA processing
mRNA splicing, via spliceosome
mRNA transport
negative regulation of telomere maintenance via telomerase
nuclear export
nuclear import
positive regulation of telomere maintenance via telomerase
RNA export from nucleus
RNA splicing
viral process - Gene Ontology Biological Process:
- gene expression
mRNA processing
mRNA splicing, via spliceosome
mRNA transport
negative regulation of telomere maintenance via telomerase
nuclear export
nuclear import
positive regulation of telomere maintenance via telomerase
RNA export from nucleus
RNA splicing
viral process - Gene Ontology Molecular Function:
- G-rich strand telomeric DNA binding
nucleotide binding
poly(A) RNA binding
RNA binding
single-stranded DNA binding
single-stranded RNA binding
telomeric repeat-containing RNA binding - Gene Ontology Cellular Component:
- catalytic step 2 spliceosome
cytoplasm
extracellular exosome
intracellular ribonucleoprotein complex
membrane
nucleoplasm
nucleus
spliceosomal complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Amyotrophic lateral sclerosis
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Host-virus interaction
Isopeptide bond
Methylation
Neurodegeneration
Nucleus
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Repeat
Ribonucleoprotein
Spliceosome
Transport
Ubl conjugation
mRNA processing
mRNA splicing
mRNA transport - Interacts With:
- P27958; P31942; Q07666; Q14141; Q9UHD9
Publication
- PubMed ID:
- 2760922 2836799 14702039 16541075 15489334 3023065 1691095 7730395 8521471 7769000 11991638 15782174 15161980 16111636 17081983 17924679 17229681 17289661 19367720 18669648 19413330 19690332 19608861 20068231 21269460 21406692 22814378 24549040 24275569 25755297 25944712 2176620 9164463 9115444 23455423 25616961