Names & Taxonomy
- Uniprot ID:
- P09622
- Entry Name:
- DLDH_HUMAN
- Status:
- reviewed
- Protein Names:
- Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)
- Gene Names:
- DLD GCSL LAD PHE3
- Gene Names Primary:
- DLD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 509
- Sequence:
- MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
- Catalytic Activity:
- Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Active Site:
- ACT_SITE 487 487 Proton acceptor.
- Cross Reference Drug Bank:
- DB03147
- Gene Ontology Go:
- acrosomal matrix
cilium
mitochondrial matrix
mitochondrion
myelin sheath
nucleoplasm
oxoglutarate dehydrogenase complex
pyruvate dehydrogenase complex
dihydrolipoyl dehydrogenase activity
flavin adenine dinucleotide binding
lipoamide binding
NAD binding
2-oxoglutarate metabolic process
aging
branched-chain amino acid catabolic process
cell redox homeostasis
cellular metabolic process
cellular nitrogen compound metabolic process
dihydrolipoamide metabolic process
gastrulation
glyoxylate metabolic process
lipoate metabolic process
lysine catabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
mitochondrial electron transport, NADH to ubiquinone
proteolysis
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of membrane potential
small molecule metabolic process
sperm capacitation
tricarboxylic acid cycle - Gene Ontology Biological Process:
- 2-oxoglutarate metabolic process
aging
branched-chain amino acid catabolic process
cell redox homeostasis
cellular metabolic process
cellular nitrogen compound metabolic process
dihydrolipoamide metabolic process
gastrulation
glyoxylate metabolic process
lipoate metabolic process
lysine catabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
mitochondrial electron transport, NADH to ubiquinone
proteolysis
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of membrane potential
small molecule metabolic process
sperm capacitation
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- dihydrolipoyl dehydrogenase activity
flavin adenine dinucleotide binding
lipoamide binding
NAD binding - Gene Ontology Cellular Component:
- acrosomal matrix
cilium
mitochondrial matrix
mitochondrion
myelin sheath
nucleoplasm
oxoglutarate dehydrogenase complex
pyruvate dehydrogenase complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
FAD
Flavoprotein
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Redox-active center
Reference proteome
Transit peptide