Names & Taxonomy
- Uniprot ID:
- P09619
- Entry Name:
- PGFRB_HUMAN
- Status:
- reviewed
- Protein Names:
- Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
- Gene Names:
- PDGFRB PDGFR PDGFR1
- Gene Names Primary:
- PDGFRB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1106
- Sequence:
- MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Function
- Function:
- Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFB and/or PDGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib.
- Active Site:
- ACT_SITE 826 826 Proton acceptor.
- Cross Reference Drug Bank:
- DB00102 DB01254 DB00619 DB06589 DB08896 DB00398 DB01268
- Gene Ontology Go:
- apical plasma membrane
cytoplasm
cytoplasmic, membrane-bounded vesicle
extracellular exosome
focal adhesion
integral component of membrane
intrinsic component of plasma membrane
lysosomal lumen
membrane
nucleus
plasma membrane
ATP binding
platelet activating factor receptor activity
platelet-derived growth factor beta-receptor activity
platelet-derived growth factor binding
platelet-derived growth factor receptor binding
platelet-derived growth factor-activated receptor activity
protein kinase binding
protein tyrosine kinase activity
receptor binding
vascular endothelial growth factor binding
activation of MAPKK activity
aorta morphogenesis
axon guidance
cardiac myofibril assembly
cell chemotaxis
cell migration
cell migration involved in coronary angiogenesis
cell migration involved in vasculogenesis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
glycosaminoglycan biosynthetic process
innate immune response
inner ear development
insulin receptor signaling pathway
MAPK cascade
metanephric comma-shaped body morphogenesis
metanephric glomerular capillary formation
metanephric glomerular mesangial cell proliferation involved in metanephros development
metanephric mesenchymal cell migration
metanephric mesenchyme development
metanephric S-shaped body morphogenesis
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine phosphorylation
phosphatidylinositol metabolic process
phosphatidylinositol-mediated signaling
platelet-derived growth factor receptor signaling pathway
platelet-derived growth factor receptor-beta signaling pathway
positive regulation of calcium ion import
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
positive regulation of chemotaxis
positive regulation of collagen biosynthetic process
positive regulation of DNA biosynthetic process
positive regulation of ERK1 and ERK2 cascade
positive regulation of MAP kinase activity
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
positive regulation of mitotic nuclear division
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phospholipase C activity
positive regulation of phosphoprotein phosphatase activity
positive regulation of reactive oxygen species metabolic process
positive regulation of smooth muscle cell migration
positive regulation of smooth muscle cell proliferation
protein autophosphorylation
Ras protein signal transduction
regulation of actin cytoskeleton organization
response to estradiol
response to fluid shear stress
response to hydrogen peroxide
response to hyperoxia
response to retinoic acid
response to toxic substance
retina vasculature development in camera-type eye
signal transduction
small GTPase mediated signal transduction
smooth muscle cell chemotaxis
vascular endothelial growth factor receptor signaling pathway
wound healing - Gene Ontology Biological Process:
- activation of MAPKK activity
aorta morphogenesis
axon guidance
cardiac myofibril assembly
cell chemotaxis
cell migration
cell migration involved in coronary angiogenesis
cell migration involved in vasculogenesis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glycosaminoglycan biosynthetic process
G-protein coupled receptor signaling pathway
innate immune response
inner ear development
insulin receptor signaling pathway
MAPK cascade
metanephric comma-shaped body morphogenesis
metanephric glomerular capillary formation
metanephric glomerular mesangial cell proliferation involved in metanephros development
metanephric mesenchymal cell migration
metanephric mesenchyme development
metanephric S-shaped body morphogenesis
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine phosphorylation
phosphatidylinositol-mediated signaling
phosphatidylinositol metabolic process
platelet-derived growth factor receptor-beta signaling pathway
platelet-derived growth factor receptor signaling pathway
positive regulation of calcium ion import
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
positive regulation of chemotaxis
positive regulation of collagen biosynthetic process
positive regulation of DNA biosynthetic process
positive regulation of ERK1 and ERK2 cascade
positive regulation of MAP kinase activity
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
positive regulation of mitotic nuclear division
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phospholipase C activity
positive regulation of phosphoprotein phosphatase activity
positive regulation of reactive oxygen species metabolic process
positive regulation of smooth muscle cell migration
positive regulation of smooth muscle cell proliferation
protein autophosphorylation
Ras protein signal transduction
regulation of actin cytoskeleton organization
response to estradiol
response to fluid shear stress
response to hydrogen peroxide
response to hyperoxia
response to retinoic acid
response to toxic substance
retina vasculature development in camera-type eye
signal transduction
small GTPase mediated signal transduction
smooth muscle cell chemotaxis
vascular endothelial growth factor receptor signaling pathway
wound healing - Gene Ontology Molecular Function:
- ATP binding
platelet activating factor receptor activity
platelet-derived growth factor-activated receptor activity
platelet-derived growth factor beta-receptor activity
platelet-derived growth factor binding
platelet-derived growth factor receptor binding
protein kinase binding
protein tyrosine kinase activity
receptor binding
vascular endothelial growth factor binding - Gene Ontology Cellular Component:
- apical plasma membrane
cytoplasm
cytoplasmic, membrane-bounded vesicle
extracellular exosome
focal adhesion
integral component of membrane
intrinsic component of plasma membrane
lysosomal lumen
membrane
nucleus
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell membrane
Chemotaxis
Chromosomal rearrangement
Complete proteome
Cytoplasmic vesicle
Developmental protein
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Kinase
Lysosome
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Proto-oncogene
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation - Interacts With:
- P0CK45; P06241; Q14451; Q53G59; P01127; P23727; P27986; P08487; P19174; P60484; P18031; Q06124; Q05209; Q12913; P04049; P20936; Q13239; O14745; Q15654; P25020
Publication
- PubMed ID:
- 2835772 2850496 18593464 15372022 15489334 9285559 21938754 2846185 15340161 2550144 2554309 1653029 1709159 1846866 1314164 1396585 1313434 1375321 7685273 7679113 7691811 7692233 8302579 8940081 9373237 10454568 9989826 10821867 10805725 11297552 11331881 12181402 12907457 15087372 15492236 14966296 15902258 17620338 21098708 20494825 20529858 21733313 8195171 21679854 26599395 9739761 15207817 17419949 18483217 11567151 11882663 20534510 17344846 23731542 23731537 24065723 23255827