Names & Taxonomy
- Uniprot ID:
- P09238
- Entry Name:
- MMP10_HUMAN
- Status:
- reviewed
- Protein Names:
- Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2)
- Gene Names:
- MMP10 STMY2
- Gene Names Primary:
- MMP10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 476
- Sequence:
- MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
- Catalytic Activity:
- Similar to stromelysin 1, but action on collagen types III, IV and V is weak.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 218 218
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular region
extracellular space
proteinaceous extracellular matrix
calcium ion binding
metalloendopeptidase activity
zinc ion binding
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
proteolysis
regulation of cell migration - Gene Ontology Biological Process:
- collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
proteolysis
regulation of cell migration - Gene Ontology Molecular Function:
- calcium ion binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Calcium
Collagen degradation
Complete proteome
Disulfide bond
Extracellular matrix
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen