Names & Taxonomy
- Uniprot ID:
- P09172
- Entry Name:
- DOPO_HUMAN
- Status:
- reviewed
- Protein Names:
- Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase]
- Gene Names:
- DBH
- Gene Names Primary:
- DBH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 617
- Sequence:
- MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQGRSPAGPTVVSIGGGKG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen.; Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane
Function
- Function:
- Conversion of dopamine to noradrenaline.
- Pathway:
- Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
- Catalytic Activity:
- 3,4-dihydroxyphenethylamine + ascorbate + O(2) = noradrenaline + dehydroascorbate + H(2)O.
- Cofactor:
- COFACTOR: Name=pyrroloquinoline quinone; Xref=ChEBI:CHEBI:58442; ; Note=Binds 1 PQQ per subunit.;; COFACTOR: Name=Cu(2+); Xref=ChEBI:CHEBI:29036; ; Note=Binds 2 copper ions per subunit.;
- Active Site:
- ACT_SITE 230 230
- Cross Reference Drug Bank:
- DB06774 DB00822 DB00988 DB00550 DB00126
- Gene Ontology Go:
- chromaffin granule lumen
chromaffin granule membrane
cytoplasm
extracellular region
integral component of membrane
membrane
secretory granule lumen
transport vesicle membrane
catalytic activity
copper ion binding
dopamine beta-monooxygenase activity
L-ascorbic acid binding
behavioral response to ethanol
blood vessel remodeling
catecholamine biosynthetic process
cellular nitrogen compound metabolic process
cytokine production
dopamine catabolic process
fear response
glucose homeostasis
homoiothermy
leukocyte mediated immunity
leukocyte migration
locomotory behavior
maternal behavior
memory
norepinephrine biosynthetic process
positive regulation of vasoconstriction
regulation of cell proliferation
regulation of extrinsic apoptotic signaling pathway
response to amphetamine
response to pain
small molecule metabolic process
synaptic transmission
visual learning - Gene Ontology Biological Process:
- behavioral response to ethanol
blood vessel remodeling
catecholamine biosynthetic process
cellular nitrogen compound metabolic process
cytokine production
dopamine catabolic process
fear response
glucose homeostasis
homoiothermy
leukocyte mediated immunity
leukocyte migration
locomotory behavior
maternal behavior
memory
norepinephrine biosynthetic process
positive regulation of vasoconstriction
regulation of cell proliferation
regulation of extrinsic apoptotic signaling pathway
response to amphetamine
response to pain
small molecule metabolic process
synaptic transmission
visual learning - Gene Ontology Molecular Function:
- catalytic activity
copper ion binding
dopamine beta-monooxygenase activity
L-ascorbic acid binding - Gene Ontology Cellular Component:
- chromaffin granule lumen
chromaffin granule membrane
cytoplasm
extracellular region
integral component of membrane
membrane
secretory granule lumen
transport vesicle membrane - Keywords:
- Catecholamine biosynthesis
Complete proteome
Copper
Cytoplasmic vesicle
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Metal-binding
Monooxygenase
Oxidoreductase
PQQ
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Vitamin C