Names & Taxonomy
- Uniprot ID:
- P09110
- Entry Name:
- THIK_HUMAN
- Status:
- reviewed
- Protein Names:
- 3-ketoacyl-CoA thiolase, peroxisomal (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Peroxisomal 3-oxoacyl-CoA thiolase)
- Gene Names:
- ACAA1 ACAA PTHIO
- Gene Names Primary:
- ACAA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 424
- Sequence:
- MQRLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQCSSGLQAVASIAGGIRNGSYDIGMACGVESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPVALQKAGLTVSDVDIFEINEAFASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFEYPGN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome.
Function
- Pathway:
- Lipid metabolism; fatty acid metabolism.
- Catalytic Activity:
- Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
- Active Site:
- ACT_SITE 123 123 Acyl-thioester intermediate.
- Cross Reference Drug Bank:
- DB09069
- Gene Ontology Go:
- intracellular membrane-bounded organelle
membrane
peroxisomal matrix
peroxisome
acetyl-CoA C-acyltransferase activity
palmitoyl-CoA oxidase activity
alpha-linolenic acid metabolic process
bile acid metabolic process
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA oxidase
small molecule metabolic process
unsaturated fatty acid metabolic process
very long-chain fatty acid metabolic process - Gene Ontology Biological Process:
- alpha-linolenic acid metabolic process
bile acid metabolic process
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA oxidase
small molecule metabolic process
unsaturated fatty acid metabolic process
very long-chain fatty acid metabolic process - Gene Ontology Molecular Function:
- acetyl-CoA C-acyltransferase activity
palmitoyl-CoA oxidase activity - Gene Ontology Cellular Component:
- intracellular membrane-bounded organelle
membrane
peroxisomal matrix
peroxisome - Keywords:
- 3D-structure
Acyltransferase
Alternative splicing
Complete proteome
Fatty acid metabolism
Lipid metabolism
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Transit peptide