Names & Taxonomy
- Uniprot ID:
- P09086
- Entry Name:
- PO2F2_HUMAN
- Status:
- reviewed
- Protein Names:
- POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)
- Gene Names:
- POU2F2 OCT2 OTF2
- Gene Names Primary:
- POU2F2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 479
- Sequence:
- MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPSTKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLSHPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.
- Cross Reference Drug Bank:
- DB08930
- Gene Ontology Go:
- cytoplasm
nucleus
RNA polymerase II core promoter proximal region sequence-specific DNA binding
sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
cell maturation
humoral immune response
immunoglobulin secretion involved in immune response
mature B cell differentiation
transcription from RNA polymerase II promoter - Gene Ontology Biological Process:
- cell maturation
humoral immune response
immunoglobulin secretion involved in immune response
mature B cell differentiation
transcription from RNA polymerase II promoter - Gene Ontology Molecular Function:
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding - Gene Ontology Cellular Component:
- cytoplasm
nucleus - Keywords:
- 3D-structure
Activator
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Homeobox
Nucleus
Reference proteome
Transcription
Transcription regulation