Names & Taxonomy

Uniprot ID:
P09038
Entry Name:
FGF2_HUMAN
Status:
reviewed
Protein Names:
Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)
Gene Names:
FGF2 FGFB
Gene Names Primary:
FGF2
Organism:
Homo sapiens (Human)

Structure

Length:
288
Sequence:
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.

Function

Function:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Cross Reference Drug Bank:
DB00686 DB00877 DB00364
Gene Ontology Go:
extracellular region
extracellular space
nucleus
chemoattractant activity
cytokine activity
fibroblast growth factor receptor binding
growth factor activity
heparin binding
ligand-dependent nuclear receptor transcription coactivator activity
activation of MAPK activity
activation of MAPKK activity
axon guidance
branching involved in ureteric bud morphogenesis
cell migration involved in sprouting angiogenesis
chemotaxis
chondroblast differentiation
embryonic morphogenesis
epidermal growth factor receptor signaling pathway
extracellular matrix organization
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
growth factor dependent regulation of skeletal muscle satellite cell proliferation
hyaluronan catabolic process
innate immune response
inositol phosphate biosynthetic process
insulin receptor signaling pathway
MAPK cascade
negative regulation of blood vessel endothelial cell migration
negative regulation of cell death
negative regulation of fibroblast migration
negative regulation of wound healing
nervous system development
neurotrophin TRK receptor signaling pathway
organ morphogenesis
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
positive chemotaxis
positive regulation of angiogenesis
positive regulation of blood vessel endothelial cell migration
positive regulation of cardiac muscle cell proliferation
positive regulation of cell division
positive regulation of cell fate specification
positive regulation of cell proliferation
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of MAP kinase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of phospholipase C activity
positive regulation of sprouting angiogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
Ras protein signal transduction
regulation of angiogenesis
regulation of endothelial cell chemotaxis to fibroblast growth factor
release of sequestered calcium ion into cytosol
signal transduction
small GTPase mediated signal transduction
somatic stem cell population maintenance
vascular endothelial growth factor receptor signaling pathway
wound healing
Gene Ontology Biological Process:
activation of MAPK activity
activation of MAPKK activity
axon guidance
branching involved in ureteric bud morphogenesis
cell migration involved in sprouting angiogenesis
chemotaxis
chondroblast differentiation
embryonic morphogenesis
epidermal growth factor receptor signaling pathway
extracellular matrix organization
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
growth factor dependent regulation of skeletal muscle satellite cell proliferation
hyaluronan catabolic process
innate immune response
inositol phosphate biosynthetic process
insulin receptor signaling pathway
MAPK cascade
negative regulation of blood vessel endothelial cell migration
negative regulation of cell death
negative regulation of fibroblast migration
negative regulation of wound healing
nervous system development
neurotrophin TRK receptor signaling pathway
organ morphogenesis
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
positive chemotaxis
positive regulation of angiogenesis
positive regulation of blood vessel endothelial cell migration
positive regulation of cardiac muscle cell proliferation
positive regulation of cell division
positive regulation of cell fate specification
positive regulation of cell proliferation
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of MAP kinase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of phospholipase C activity
positive regulation of sprouting angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
Ras protein signal transduction
regulation of angiogenesis
regulation of endothelial cell chemotaxis to fibroblast growth factor
release of sequestered calcium ion into cytosol
signal transduction
small GTPase mediated signal transduction
somatic stem cell population maintenance
vascular endothelial growth factor receptor signaling pathway
wound healing
Gene Ontology Molecular Function:
chemoattractant activity
cytokine activity
fibroblast growth factor receptor binding
growth factor activity
heparin binding
ligand-dependent nuclear receptor transcription coactivator activity
Gene Ontology Cellular Component:
extracellular region
extracellular space
nucleus
Keywords:
3D-structure
Alternative initiation
Angiogenesis
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Growth factor
Heparin-binding
Methylation
Mitogen
Nucleus
Phosphoprotein
Reference proteome
Secreted
Interacts With:
P29466; Q14512; P11362; P11362-14; P21802

Publication

PubMed ID:
3472745 3780670 2538817 19054851 15815621 1785797 2435575 1721615 8564983 3579930 2435284 3964259 3732516 1417798 1885605 8663044 10358027 11509569 11964394 16257968 18669637 20230531 15863030 20094046 22321063 1769963 1707542 1849658 1702556 7691311 11390973 8885834