Names & Taxonomy
- Uniprot ID:
- P08913
- Entry Name:
- ADA2A_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR)
- Gene Names:
- ADRA2A ADRA2R ADRAR
- Gene Names Primary:
- ADRA2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 450
- Sequence:
- MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
- Cross Reference Drug Bank:
- DB00321 DB00543 DB00182 DB00714 DB00964 DB01238 DB06216 DB00865 DB00217 DB00484 DB01200 DB00248 DB01136 DB00477 DB00575 DB00363 DB01151 DB00633 DB00320 DB00449 DB01142 DB04855 DB06262 DB01363 DB00751 DB00668 DB01049 DB00696 DB00800 DB06623 DB00629 DB01018 DB00589 DB04948 DB00408 DB08815 DB00934 DB01365 DB01577 DB01403 DB00968 DB06148 DB00370 DB06711 DB01149 DB00368 DB00540 DB00334 DB00935 DB01267 DB01186 DB00925 DB00692 DB00397 DB00413 DB00457 DB01608 DB00852 DB01224 DB00734 DB00268 DB00697 DB00797 DB00656 DB00726 DB06694 DB01392 DB00246 DB01624
- Gene Ontology Go:
- basolateral plasma membrane
cytoplasm
integral component of plasma membrane
plasma membrane
receptor complex
synapse
alpha-1B adrenergic receptor binding
alpha-2C adrenergic receptor binding
alpha2-adrenergic receptor activity
epinephrine binding
heterotrimeric G-protein binding
norepinephrine binding
protein heterodimerization activity
protein homodimerization activity
protein kinase binding
thioesterase binding
actin cytoskeleton organization
activation of MAPK activity by adrenergic receptor signaling pathway
activation of protein kinase activity
activation of protein kinase B activity
acute inflammatory response
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
blood coagulation
cell-cell signaling
cellular response to hormone stimulus
DNA replication
energy reserve metabolic process
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
female pregnancy
G-protein coupled receptor signaling pathway
glucose homeostasis
intestinal absorption
movement of cell or subcellular component
negative regulation of adenylate cyclase activity
negative regulation of adrenergic receptor signaling pathway
negative regulation of calcium ion transmembrane transporter activity
negative regulation of calcium ion transport
negative regulation of calcium ion-dependent exocytosis
negative regulation of cAMP biosynthetic process
negative regulation of epinephrine secretion
negative regulation of insulin secretion
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of lipid catabolic process
negative regulation of norepinephrine secretion
negative regulation of uterine smooth muscle contraction
phospholipase C-activating adrenergic receptor signaling pathway
platelet activation
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cytokine production
positive regulation of epidermal growth factor-activated receptor activity
positive regulation of MAP kinase activity
positive regulation of membrane protein ectodomain proteolysis
positive regulation of potassium ion transport
positive regulation of vasodilation
positive regulation of wound healing
Ras protein signal transduction
regulation of insulin secretion
regulation of vasoconstriction
Rho protein signal transduction
signal transduction
small molecule metabolic process
thermoception - Gene Ontology Biological Process:
- actin cytoskeleton organization
activation of MAPK activity by adrenergic receptor signaling pathway
activation of protein kinase activity
activation of protein kinase B activity
acute inflammatory response
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
blood coagulation
cell-cell signaling
cellular response to hormone stimulus
DNA replication
energy reserve metabolic process
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
female pregnancy
glucose homeostasis
G-protein coupled receptor signaling pathway
intestinal absorption
movement of cell or subcellular component
negative regulation of adenylate cyclase activity
negative regulation of adrenergic receptor signaling pathway
negative regulation of calcium ion-dependent exocytosis
negative regulation of calcium ion transmembrane transporter activity
negative regulation of calcium ion transport
negative regulation of cAMP biosynthetic process
negative regulation of epinephrine secretion
negative regulation of insulin secretion
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of lipid catabolic process
negative regulation of norepinephrine secretion
negative regulation of uterine smooth muscle contraction
phospholipase C-activating adrenergic receptor signaling pathway
platelet activation
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cytokine production
positive regulation of epidermal growth factor-activated receptor activity
positive regulation of MAP kinase activity
positive regulation of membrane protein ectodomain proteolysis
positive regulation of potassium ion transport
positive regulation of vasodilation
positive regulation of wound healing
Ras protein signal transduction
regulation of insulin secretion
regulation of vasoconstriction
Rho protein signal transduction
signal transduction
small molecule metabolic process
thermoception - Gene Ontology Molecular Function:
- alpha-1B adrenergic receptor binding
alpha2-adrenergic receptor activity
alpha-2C adrenergic receptor binding
epinephrine binding
heterotrimeric G-protein binding
norepinephrine binding
protein heterodimerization activity
protein homodimerization activity
protein kinase binding
thioesterase binding - Gene Ontology Cellular Component:
- basolateral plasma membrane
cytoplasm
integral component of plasma membrane
plasma membrane
receptor complex
synapse - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix