Names & Taxonomy
- Uniprot ID:
- P08842
- Entry Name:
- STS_HUMAN
- Status:
- reviewed
- Protein Names:
- Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)
- Gene Names:
- STS ARSC1
- Gene Names Primary:
- STS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 583
- Sequence:
- MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
Function
- Function:
- Conversion of sulfated steroid precursors to estrogens during pregnancy.
- Catalytic Activity:
- 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 136 136
- Cross Reference Drug Bank:
- DB06713
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
endosome
Golgi apparatus
integral component of membrane
intracellular membrane-bounded organelle
lysosome
membrane
nuclear envelope
plasma membrane
metal ion binding
steryl-sulfatase activity
sulfuric ester hydrolase activity
cellular protein metabolic process
epidermis development
female pregnancy
glycosphingolipid metabolic process
learning or memory
positive regulation of cell proliferation
post-translational protein modification
response to estrogen
response to peptide hormone
response to pH
skin development
small molecule metabolic process
sphingolipid metabolic process
steroid catabolic process - Gene Ontology Biological Process:
- cellular protein metabolic process
epidermis development
female pregnancy
glycosphingolipid metabolic process
learning or memory
positive regulation of cell proliferation
post-translational protein modification
response to estrogen
response to peptide hormone
response to pH
skin development
small molecule metabolic process
sphingolipid metabolic process
steroid catabolic process - Gene Ontology Molecular Function:
- metal ion binding
steryl-sulfatase activity
sulfuric ester hydrolase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
endosome
Golgi apparatus
integral component of membrane
intracellular membrane-bounded organelle
lysosome
membrane
nuclear envelope
plasma membrane - Keywords:
- 3D-structure
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Ichthyosis
Lipid metabolism
Membrane
Metal-binding
Pregnancy
Reference proteome
Signal
Steroid metabolism
Transmembrane
Transmembrane helix