Names & Taxonomy

Uniprot ID:
P08709
Entry Name:
FA7_HUMAN
Status:
reviewed
Protein Names:
Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
Gene Names:
F7
Gene Names Primary:
F7
Organism:
Homo sapiens (Human)

Structure

Length:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
Catalytic Activity:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Active Site:
ACT_SITE 253 253 Charge relay system.
Cross Reference Drug Bank:
DB00100 DB00036 DB00170
Gene Ontology Go:
endoplasmic reticulum lumen
extracellular region
extracellular space
Golgi lumen
plasma membrane
vesicle
calcium ion binding
glycoprotein binding
serine-type endopeptidase activity
serine-type peptidase activity
blood coagulation
blood coagulation, extrinsic pathway
cellular protein metabolic process
circadian rhythm
ER to Golgi vesicle-mediated transport
organ regeneration
peptidyl-glutamic acid carboxylation
positive regulation of blood coagulation
positive regulation of cell migration
positive regulation of leukocyte chemotaxis
positive regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
post-translational protein modification
response to estrogen
response to growth hormone
response to vitamin K
signal peptide processing
Gene Ontology Biological Process:
blood coagulation
blood coagulation, extrinsic pathway
cellular protein metabolic process
circadian rhythm
ER to Golgi vesicle-mediated transport
organ regeneration
peptidyl-glutamic acid carboxylation
positive regulation of blood coagulation
positive regulation of cell migration
positive regulation of leukocyte chemotaxis
positive regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
post-translational protein modification
response to estrogen
response to growth hormone
response to vitamin K
signal peptide processing
Gene Ontology Molecular Function:
calcium ion binding
glycoprotein binding
serine-type endopeptidase activity
serine-type peptidase activity
Gene Ontology Cellular Component:
endoplasmic reticulum lumen
extracellular region
extracellular space
Golgi lumen
plasma membrane
vesicle
Keywords:
3D-structure
Alternative splicing
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Gamma-carboxyglutamic acid
Glycoprotein
Hemostasis
Hydrolase
Hydroxylation
Pharmaceutical
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen
Interacts With:
P13726

Publication

PubMed ID:
3486420 3037537 16292673 15057823 15489334 3264725 8043443 2511201 2129367 1904059 9023546 19167329 21949356 8598903 9925787 9692950 2070047 1634227 8364544 8242057 8204879 7860081 7981691 7974346 8652821 8844208 8940045 8883260 9414278 9576180 9452082 10391209 11091194 11129332 10862079 10984565 12472587 14717781 19751712 18976247 19432927 21206266 21372693