Names & Taxonomy
- Uniprot ID:
- P08637
- Entry Name:
- FCG3A_HUMAN
- Status:
- reviewed
- Protein Names:
- Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
- Gene Names:
- FCGR3A CD16A FCG3 FCGR3 IGFR3
- Gene Names Primary:
- FCGR3A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 254
- Sequence:
- MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKDPQDK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
- Cross Reference Drug Bank:
- DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072
- Gene Ontology Go:
- external side of plasma membrane
extracellular exosome
integral component of membrane
plasma membrane
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response
innate immune response
regulation of immune response - Gene Ontology Biological Process:
- Fc-gamma receptor signaling pathway involved in phagocytosis
immune response
innate immune response
regulation of immune response - Gene Ontology Cellular Component:
- external side of plasma membrane
extracellular exosome
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
IgG-binding protein
Immunoglobulin domain
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix