Names & Taxonomy
- Uniprot ID:
- P08603
- Entry Name:
- CFAH_HUMAN
- Status:
- reviewed
- Protein Names:
- Complement factor H (H factor 1)
- Gene Names:
- CFH HF HF1 HF2
- Gene Names Primary:
- CFH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1231
- Sequence:
- MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.
- Gene Ontology Go:
- blood microparticle
extracellular exosome
extracellular region
extracellular space
heparan sulfate proteoglycan binding
heparin binding
complement activation
complement activation, alternative pathway
innate immune response
regulation of complement activation - Gene Ontology Biological Process:
- complement activation
complement activation, alternative pathway
innate immune response
regulation of complement activation - Gene Ontology Molecular Function:
- heparan sulfate proteoglycan binding
heparin binding - Gene Ontology Cellular Component:
- blood microparticle
extracellular exosome
extracellular region
extracellular space - Keywords:
- 3D-structure
Age-related macular degeneration
Alternative splicing
Complement alternate pathway
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemolytic uremic syndrome
Immunity
Innate immunity
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Sushi - Interacts With:
- P01024; P16946
Publication
- PubMed ID:
- 2963625 16710414 15489334 2946589 2937845 1826708 6215918 14760718 16335952 17591618 19159218 19139490 19838169 24275569 1829116 1533152 8331663 9312129 9551389 10577907 10762557 10803850 11170895 11170896 11158219 11851332 12020532 14583443 12960213 14978182 15895326 15870199 15761122 15761120 15761121 16612335 18252232 20513133 22028381 22019782