Names & Taxonomy

Uniprot ID:
P08311
Entry Name:
CATG_HUMAN
Status:
reviewed
Protein Names:
Cathepsin G (CG) (EC 3.4.21.20)
Gene Names:
CTSG
Gene Names Primary:
CTSG
Organism:
Homo sapiens (Human)

Structure

Length:
255
Sequence:
MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell surface

Function

Function:
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
Catalytic Activity:
Specificity similar to chymotrypsin C.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.15 mM for Z-Lys-SBzl
Enzyme Regulation:
ENZYME REGULATION: Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and ETDA.
Active Site:
ACT_SITE 64 64 Charge relay system.; ACT_SITE 108 108 Charge relay system.; ACT_SITE 201 201 Charge relay system.
Gene Ontology Go:
cell surface
extracellular exosome
extracellular region
extracellular space
nucleus
plasma membrane
secretory granule
heparin binding
peptidase activity
serine-type endopeptidase activity
angiotensin maturation
cellular protein metabolic process
defense response to fungus
extracellular matrix disassembly
extracellular matrix organization
immune response
negative regulation of growth of symbiont in host
neutrophil mediated killing of gram-positive bacterium
positive regulation of immune response
protein phosphorylation
protein processing
proteolysis
response to lipopolysaccharide
Gene Ontology Biological Process:
angiotensin maturation
cellular protein metabolic process
defense response to fungus
extracellular matrix disassembly
extracellular matrix organization
immune response
negative regulation of growth of symbiont in host
neutrophil mediated killing of gram-positive bacterium
positive regulation of immune response
protein phosphorylation
protein processing
proteolysis
response to lipopolysaccharide
Gene Ontology Molecular Function:
heparin binding
peptidase activity
serine-type endopeptidase activity
Gene Ontology Cellular Component:
cell surface
extracellular exosome
extracellular region
extracellular space
nucleus
plasma membrane
secretory granule
Keywords:
3D-structure
Antibiotic
Antimicrobial
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease
Reference proteome
Serine protease
Signal
Zymogen
Interacts With:
Q15323; Q7Z3S9

Publication

PubMed ID:
3304423 2569462 15489334 8194606 3799965 2501794 1861080 7897245 1937776 21269460 25944712 8896442 8454293