Names & Taxonomy
- Uniprot ID:
- P08183
- Entry Name:
- MDR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243)
- Gene Names:
- ABCB1 MDR1 PGY1
- Gene Names Primary:
- ABCB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1280
- Sequence:
- MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
- Catalytic Activity:
- ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
- Cross Reference Drug Bank:
- DB01193 DB00316 DB00945 DB00171 DB05773 DB08916 DB00518 DB11363 DB00802 DB00523 DB00915 DB06403 DB00345 DB01118 DB00321 DB00381 DB00701 DB00276 DB06605 DB01169 DB00637 DB01072 DB00335 DB01076 DB06626 DB00972 DB00207 DB01086 DB01244 DB00443 DB00810 DB08873 DB06616 DB08870 DB01200 DB00921 DB00490 DB06772 DB00201 DB08907 DB00796 DB01197 DB00564 DB08889 DB01136 DB00520 DB09063 DB00608 DB00477 DB00672 DB01239 DB02659 DB01340 DB00501 DB00537 DB00515 DB00215 DB01211 DB00349 DB00845 DB00882 DB01242 DB00575 DB00758 DB00257 DB00363 DB09065 DB05239 DB01394 DB00286 DB08865 DB00531 DB00091 DB06695 DB08912 DB09102 DB00970 DB06292 DB01254 DB00694 DB04840 DB01151 DB00967 DB01234 DB00514 DB00829 DB00586 DB00255 DB01396 DB00390 DB00320 DB00343 DB00975 DB01248 DB01184 DB00590 DB01142 DB00997 DB00470 DB04855 DB09075 DB00216 DB00584 DB08899 DB00751 DB01253 DB00696 DB00530 DB00199 DB00783 DB01196 DB04573 DB00655 DB00977 DB00773 DB06414 DB00973 DB01023 DB00813 DB06702 DB00950 DB08874 DB00196 DB00472 DB00875 DB00623 DB00690 DB08906 DB00176 DB00317 DB00441 DB01016 DB00027 DB00502 DB00741 DB01050 DB09054 DB00619 DB00458 DB05039 DB00224 DB00328 DB00762 DB06636 DB01167 DB08820 DB00602 DB01221 DB01587 DB01026 DB00709 DB00555 DB00448 DB01259 DB00480 DB09078 DB01202 DB01137 DB08918 DB00451 DB00281 DB08882 DB00279 DB01583 DB00722 DB08827 DB00836 DB01601 DB00455 DB00678 DB00227 DB00742 DB00934 DB00643 DB00358 DB00351 DB00371 DB00333 DB00563 DB00959 DB00264 DB01110 DB00683 DB00834 DB08893 DB00305 DB01204 DB00295 DB00688 DB01203 DB01183 DB00704 DB01149 DB00220 DB01400 DB00622 DB01115 DB04868 DB09079 DB00401 DB01595 DB01054 DB00585 DB00717 DB00334 DB00338 DB09330 DB01229 DB06603 DB00213 DB00715 DB06589 DB00790 DB01174 DB00252 DB01100 DB08860 DB08910 DB08901 DB01263 DB00175 DB00457 DB00860 DB00635 DB01032 DB00396 DB01069 DB01182 DB00571 DB00344 DB01224 DB01103 DB00908 DB00468 DB00863 DB00234 DB08896 DB00206 DB01045 DB08864 DB00734 DB00503 DB06228 DB09291 DB00778 DB00936 DB01232 DB00747 DB01037 DB11362 DB01104 DB06207 DB06290 DB00641 DB00877 DB01261 DB08934 DB00398 DB01208 DB00421 DB00428 DB01138 DB00669 DB01268 DB00864 DB00675 DB05521 DB00966 DB06287 DB01162 DB00624 DB08816 DB00373 DB06212 DB01030 DB00539 DB00656 DB00831 DB00508 DB00440 DB00726 DB01361 DB08867 DB09076 DB01339 DB00285 DB00661 DB00570 DB00541 DB00361 DB08828 DB04877 DB00495
- Gene Ontology Go:
- cell surface
extracellular exosome
integral component of membrane
membrane
plasma membrane
ATP binding
ATPase activity, coupled to transmembrane movement of substances
transporter activity
xenobiotic-transporting ATPase activity
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
drug transmembrane transport
G2/M transition of mitotic cell cycle
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
response to drug
small molecule metabolic process
stem cell proliferation
transmembrane transport
transport - Gene Ontology Biological Process:
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
drug transmembrane transport
G2/M transition of mitotic cell cycle
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
response to drug
small molecule metabolic process
stem cell proliferation
transmembrane transport
transport - Gene Ontology Molecular Function:
- ATPase activity, coupled to transmembrane movement of substances
ATP binding
transporter activity
xenobiotic-transporting ATPase activity - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
integral component of membrane
membrane
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Hydrolase
Membrane
Nucleotide-binding
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q86VI4; Q99496