Names & Taxonomy

Uniprot ID:
P08172
Entry Name:
ACM2_HUMAN
Status:
reviewed
Protein Names:
Muscarinic acetylcholine receptor M2
Gene Names:
CHRM2
Gene Names Primary:
CHRM2
Organism:
Homo sapiens (Human)

Structure

Length:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization.

Function

Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Cross Reference Drug Bank:
DB08897 DB00321 DB00543 DB00517 DB01238 DB00572 DB01019 DB00835 DB00411 DB01239 DB00568 DB00363 DB00907 DB00785 DB00434 DB00496 DB01151 DB00804 DB08801 DB01231 DB00280 DB01135 DB01142 DB00392 DB06702 DB01148 DB00483 DB00986 DB00725 DB00424 DB00458 DB00332 DB01221 DB00408 DB00934 DB01403 DB00462 DB00340 DB01336 DB01226 DB00622 DB00540 DB00334 DB01062 DB00383 DB01337 DB00715 DB00454 DB01085 DB01338 DB00387 DB00420 DB01069 DB00777 DB01224 DB00728 DB00747 DB01591 DB00202 DB01409 DB01036 DB00508 DB00376 DB00726 DB00809 DB09076 DB00246
Gene Ontology Go:
asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
neuronal cell body
plasma membrane
postsynaptic membrane
symmetric synapse
synapse
drug binding
G-protein coupled acetylcholine receptor activity
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
nervous system development
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
regulation of heart contraction
regulation of smooth muscle contraction
response to virus
synaptic transmission, cholinergic
Gene Ontology Biological Process:
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
nervous system development
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
regulation of heart contraction
regulation of smooth muscle contraction
response to virus
synaptic transmission, cholinergic
Gene Ontology Molecular Function:
drug binding
G-protein coupled acetylcholine receptor activity
Gene Ontology Cellular Component:
asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
neuronal cell body
plasma membrane
postsynaptic membrane
symmetric synapse
synapse
Keywords:
3D-structure
Cell junction
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Synapse
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
3037705 3443095 15489334 15014171 7822302 16548883 15229186 20976005 22278061 24256733