Names & Taxonomy
- Uniprot ID:
- P07947
- Entry Name:
- YES_HUMAN
- Status:
- reviewed
- Protein Names:
- Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
- Gene Names:
- YES1 YES
- Gene Names Primary:
- YES1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 543
- Sequence:
- MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
Function
- Function:
- Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 396 396 Proton acceptor.
- Cross Reference Drug Bank:
- DB01254
- Gene Ontology Go:
- actin filament
cytoplasm
cytosol
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
focal adhesion
Golgi apparatus
microtubule organizing center
plasma membrane
ATP binding
enzyme binding
ion channel binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity
receptor binding
axon guidance
blood coagulation
cell differentiation
cellular protein modification process
cellular response to platelet-derived growth factor stimulus
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
glucose transport
innate immune response
leukocyte migration
peptidyl-tyrosine autophosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of transcription from RNA polymerase II promoter
regulation of cell proliferation
regulation of vascular permeability
T cell costimulation
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- axon guidance
blood coagulation
cell differentiation
cellular protein modification process
cellular response to platelet-derived growth factor stimulus
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
glucose transport
innate immune response
leukocyte migration
peptidyl-tyrosine autophosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of transcription from RNA polymerase II promoter
regulation of cell proliferation
regulation of vascular permeability
T cell costimulation
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Molecular Function:
- ATP binding
enzyme binding
ion channel binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity
receptor binding - Gene Ontology Cellular Component:
- actin filament
cytoplasm
cytosol
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
focal adhesion
Golgi apparatus
microtubule organizing center
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Lipoprotein
Membrane
Myristate
Nucleotide-binding
Palmitate
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
SH2 domain
SH3 domain
Transferase
Tyrosine-protein kinase - Interacts With:
- P09917; P10275; Q6P1W5; P00533; Q8IVP5; P51116; Q13480; P10721; Q9H204; P08581; Q9GZT8; Q8TAK6; I6L996; O14543; Q9BWW4; Q9NVV9; Q12933; Q9Y4K3; Q96BR9