Names & Taxonomy

Uniprot ID:
P07911
Entry Name:
UROM_HUMAN
Status:
reviewed
Protein Names:
Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]
Gene Names:
UMOD
Gene Names Primary:
UMOD
Organism:
Homo sapiens (Human)

Structure

Length:
640
Sequence:
MGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDGLTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHCHALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTLDEYWRSTEYGEGYACDTDLRGWYRFVGQGGARMAETCVPVLRCNTAAPMWLNGTHPSSDEGIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLNLGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane

Function

Function:
Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515).
Gene Ontology Go:
anchored component of membrane
apical plasma membrane
basolateral plasma membrane
ciliary membrane
cytoplasmic vesicle
extracellular exosome
extracellular space
extrinsic component of membrane
Golgi apparatus
membrane raft
primary cilium
spindle pole
calcium ion binding
IgG binding
cellular defense response
chemical homeostasis
excretion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
metanephric ascending thin limb development
metanephric distal convoluted tubule development
metanephric thick ascending limb development
negative regulation of cell proliferation
neutrophil migration
regulation of ion homeostasis
response to organic substance
Gene Ontology Biological Process:
cellular defense response
chemical homeostasis
excretion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
metanephric ascending thin limb development
metanephric distal convoluted tubule development
metanephric thick ascending limb development
negative regulation of cell proliferation
neutrophil migration
regulation of ion homeostasis
response to organic substance
Gene Ontology Molecular Function:
calcium ion binding
IgG binding
Gene Ontology Cellular Component:
anchored component of membrane
apical plasma membrane
basolateral plasma membrane
ciliary membrane
cytoplasmic vesicle
extracellular exosome
extracellular space
extrinsic component of membrane
Golgi apparatus
membrane raft
primary cilium
spindle pole
Keywords:
3D-structure
Alternative splicing
Cell membrane
Cell projection
Ciliopathy
Cilium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
GPI-anchor
Glycoprotein
Lipoprotein
Membrane
Nephronophthisis
Polymorphism
Reference proteome
Repeat
Secreted
Signal

Publication

PubMed ID:
3453112 3498215 12471200 14702039 15616553 15489334 18375198 7028707 2249987 19005207 20798515 20172860 22171320 22776760 26673890 26811476 12900848 14570709 14569098 12629136 14531790 15086896 15575003 15983957 17010121 21060763 23197950 23988501 25436415