Names & Taxonomy
- Uniprot ID:
- P07911
- Entry Name:
- UROM_HUMAN
- Status:
- reviewed
- Protein Names:
- Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]
- Gene Names:
- UMOD
- Gene Names Primary:
- UMOD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 640
- Sequence:
- MGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDGLTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHCHALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTLDEYWRSTEYGEGYACDTDLRGWYRFVGQGGARMAETCVPVLRCNTAAPMWLNGTHPSSDEGIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLNLGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515).
- Gene Ontology Go:
- anchored component of membrane
apical plasma membrane
basolateral plasma membrane
ciliary membrane
cytoplasmic vesicle
extracellular exosome
extracellular space
extrinsic component of membrane
Golgi apparatus
membrane raft
primary cilium
spindle pole
calcium ion binding
IgG binding
cellular defense response
chemical homeostasis
excretion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
metanephric ascending thin limb development
metanephric distal convoluted tubule development
metanephric thick ascending limb development
negative regulation of cell proliferation
neutrophil migration
regulation of ion homeostasis
response to organic substance - Gene Ontology Biological Process:
- cellular defense response
chemical homeostasis
excretion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
metanephric ascending thin limb development
metanephric distal convoluted tubule development
metanephric thick ascending limb development
negative regulation of cell proliferation
neutrophil migration
regulation of ion homeostasis
response to organic substance - Gene Ontology Molecular Function:
- calcium ion binding
IgG binding - Gene Ontology Cellular Component:
- anchored component of membrane
apical plasma membrane
basolateral plasma membrane
ciliary membrane
cytoplasmic vesicle
extracellular exosome
extracellular space
extrinsic component of membrane
Golgi apparatus
membrane raft
primary cilium
spindle pole - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Cell projection
Ciliopathy
Cilium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
GPI-anchor
Glycoprotein
Lipoprotein
Membrane
Nephronophthisis
Polymorphism
Reference proteome
Repeat
Secreted
Signal